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Obstetrics and Gynecology International
Volume 2013 (2013), Article ID 743721, 10 pages
A Large Cohort Study of Hypothyroidism and Hyperthyroidism in Relation to Gynecologic Cancers
1Channing Division of Network Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA
2Division of Gynecologic Oncology, University of Connecticut Health Center, 263 Farmington Avenue, MC1614, Farmington, CT 06034, USA
3Division of Epidemiology & Biostatistics, Department of Community Medicine and Health Care, University of Connecticut Health Center, Farmington, CT, USA
4Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
5Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA
6Division of Endocrinology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA
Received 3 May 2013; Revised 23 June 2013; Accepted 24 June 2013
Academic Editor: Paulette Mhawech-Fauceglia
Copyright © 2013 Jae H. Kang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- R. Siegel, D. Naishadham, and A. Jemal, “Cancer statistics, 2012,” CA: A Cancer Journal for Clinicians, vol. 62, no. 1, pp. 10–29, 2012.
- P. B. Clement and R. H. Young, “Endometrioid carcinoma of the uterine corpus: a review of its pathology with emphasis on recent advances and problematic aspects,” Advances in Anatomic Pathology, vol. 9, no. 3, pp. 145–184, 2002.
- M. Inoue, “Current molecular aspects of the carcinogenesis of the uterine endometrium,” International Journal of Gynecological Cancer, vol. 11, no. 5, pp. 339–348, 2001.
- S. M. Ueda, D. S. Kapp, M. K. Cheung et al., “Trends in demographic and clinical characteristics in women diagnosed with corpus cancer and their potential impact on the increasing number of deaths,” American Journal of Obstetrics & Gynecology, vol. 198, no. 2, pp. 218.e1–218.e6, 2008.
- F. Petraglia, C. Musacchio, S. Luisi, and V. de Leo, “Hormone-dependent gynaecological disorders: a pathophysiological perspective for appropriate treatment,” Best Practice & Research Clinical Obstetrics & Gynaecology, vol. 22, no. 2, pp. 235–249, 2008.
- N. Potischman, R. N. Hoover, L. A. Brinton et al., “Case-control study of endogenous steroid hormones and endometrial cancer,” Journal of the National Cancer Institute, vol. 88, no. 16, pp. 1127–1135, 1996.
- F. Parazzini, S. Moroni, C. La Vecchia, E. Negri, D. dal Pino, and G. Bolis, “Ovarian cancer risk and history of selected medical conditions linked with female hormones,” European Journal of Cancer, vol. 33, no. 10, pp. 1634–1637, 1997.
- G. E. Krassas, K. Poppe, and D. Glinoer, “Thyroid function and human reproductive health,” Endocrine Reviews, vol. 31, no. 5, pp. 702–755, 2010.
- M. A. Adlersberg and G. N. Burrow, “Focus on primary care thyroid function and dysfunction in women,” Obstetrical & Gynecological Survey, vol. 57, no. 3, pp. S1–S7, 2002.
- G. E. Krassas, “Thyroid disease and female reproduction,” Fertility and Sterility, vol. 74, no. 6, pp. 1063–1070, 2000.
- A. Pascual and A. Aranda, “Thyroid hormone receptors, cell growth and differentiation,” Biochimica et Biophysica Acta (BBA), vol. 1830, no. 7, pp. 3908–3916, 2013.
- M. McDermott, “Hyperthyroidism,” Annals of Internal Medicine, vol. 157, no. 1, pp. 1–10, 2012.
- G. P. Redmond, “Thyroid dysfunction and women's reproductive health,” Thyroid, vol. 14, supplement 1, pp. S5–S15, 2004.
- K. Poppe and B. Velkeniers, “Female infertility and the thyroid,” Best Practice & Research Clinical Endocrinology & Metabolism, vol. 18, no. 2, pp. 153–165, 2004.
- J. L. Kirkland, V. Mukku, M. Hardy, and R. Young, “Evidence for triiodothyronine receptors in human endometrium and myometrium,” American Journal of Obstetrics & Gynecology, vol. 146, no. 4, pp. 380–383, 1983.
- R. Dittrich, M. W. Beckmann, P. G. Oppelt et al., “Thyroid hormone receptors and reproduction,” Journal of Reproductive Immunology, vol. 90, no. 1, pp. 58–66, 2011.
- E. O. Akande and T. D. Hockaday, “Plasma oestrogen and luteinizing hormone concentrations in thyrotoxic menstrual disturbance,” Proceedings of the Royal Society of Medicine, vol. 65, no. 9, pp. 789–790, 1972.
- E. O. Akande, “The effect of oestrogen on plasma levels of luteinizing hormone in euthyroid and thyrotoxic postmenopausal women,” International Journal of Obstetrics & Gynaecology, vol. 81, no. 10, pp. 795–803, 1974.
- A. Hercbergs, “The thyroid gland as an intrinsic biologic response-modifier in advanced neoplasia—a novel paradigm,” In Vivo, vol. 10, no. 2, pp. 245–247, 1996.
- A. H. Hercbergs, O. Ashur-Fabian, and D. Garfield, “Thyroid hormones and cancer: clinical studies of hypothyroidism in oncology,” Current Opinion in Endocrinology, Diabetes and Obesity, vol. 17, no. 5, pp. 432–436, 2010.
- M. Pinto, P. Soares, and D. Ribatti, “Thyroid hormone as a regulator of tumor induced angiogenesis,” Cancer Letters, vol. 301, no. 2, pp. 119–126, 2011.
- S. Y. Cheng, J. L. Leonard, and P. J. Davis, “Molecular aspects of thyroid hormone actions,” Endocrine Reviews, vol. 31, no. 2, pp. 139–170, 2010.
- L. Aghajanova, A. Stavreus-Evers, M. Lindeberg, B. Landgren, L. Sparre, and O. Hovatta, “Thyroid-stimulating hormone receptor and thyroid hormone receptors are involved in human endometrial physiology,” Fertility and Sterility, vol. 95, no. 1, pp. 230.e2–237.e2, 2011.
- J. L. P. Kuijpens, I. Nyklictek, M. W. Louwman, T. A. Weetman, V. J. Pop, and J. W. Coebergh, “Hypothyroidism might be related to breast cancer in post-menopausal women,” Thyroid, vol. 15, no. 11, pp. 1253–1259, 2005.
- G. Rennert, H. S. Rennert, M. Pinchev, and S. B. Gruber, “A case-control study of levothyroxine and the risk of colorectal cancer,” Journal of the National Cancer Institute, vol. 102, no. 8, pp. 568–572, 2010.
- E. Ron, M. M. Doody, D. V. Becker et al., “Cancer mortality following treatment for adult hyperthyroidism,” The Journal of the American Medical Association, vol. 280, no. 4, pp. 347–355, 1998.
- A. Hercbergs, H. Daw, and W. Ayoub, “Possible association of hypothyroidism with longevity in advanced colorectal and pancreatic cancer: a case study,” Thyroid, vol. 8, p. S-18, 2008.
- A. I. Hellevik, B. O. Åsvold, T. Bjøro, P. R. Romundstad, T. I. L. Nilsen, and L. J. Vatten, “Thyroid function and cancer risk: a prospective population study,” Cancer Epidemiology Biomarkers & Prevention, vol. 18, no. 2, pp. 570–574, 2009.
- L. A. Brinton, L. C. Sakoda, K. Frederiksen et al., “Relationships of uterine and ovarian tumors to pre-existing chronic conditions,” Gynecologic Oncology, vol. 107, no. 3, pp. 487–494, 2007.
- I. A. Holm, J. E. Manson, K. B. Michels, E. K. Alexander, W. C. Willett, and R. D. Utiger, “Smoking and other lifestyle factors and the risk of Graves' hyperthyroidism,” Archives of Internal Medicine, vol. 165, no. 14, pp. 1606–1611, 2005.
- M. B. Goldman, R. R. Monson, and F. Maloof, “Cancer mortality in women with thyroid disease,” Cancer Research, vol. 50, no. 8, pp. 2283–2289, 1990.
- A. G. Rosenberg, F. Dexeus, D. A. Swanson, and A. C. von Eschenbach, “Relationship of thyroid disease to renal cell carcinoma: an epidemiologic study,” Urology, vol. 35, no. 6, pp. 492–498, 1990.
- M. Cristofanilli, Y. Yamamura, S.-W. Kau et al., “Thyroid hormone and breast carcinoma. Primary hypothyroidism is associated with a reduced incidence of primary breast carcinoma,” Cancer, vol. 103, no. 6, pp. 1122–1128, 2005.
- D. A. Hoffman, W. M. McConahey, L. A. Brinton, and J. F. Fraumeni Jr., “Breast cancer in hypothyroid women using thyroid supplements,” The Journal of the American Medical Association, vol. 251, no. 5, pp. 616–619, 1984.
- P. P. Saraiva, N. B. Figueiredo, C. R. Padovani, M. M. Brentani, and C. R. Nogueira, “Profile of thyroid hormones in breast cancer patients,” Brazilian Journal of Medical and Biological Research, vol. 38, no. 5, pp. 761–765, 2005.
- P. J. Hardefeldt, G. D. Eslick, and S. Edirimanne, “Benign thyroid disease is associated with breast cancer: a meta-analysis,” Breast Cancer Research and Treatment, vol. 133, no. 3, pp. 1169–1177, 2012.
- A. Aranda, O. Martínez-Iglesias, L. Ruiz-Llorente, V. García-Carpizo, and A. Zambrano, “Thyroid receptor: roles in cancer,” Trends in Endocrinology and Metabolism, vol. 20, no. 7, pp. 318–324, 2009.
- J. L. Hecht, B. M. Dolinski, H. A. Gardner, S. M. Violette, and P. H. Weinreb, “Overexpression of the αvβ6 integrin in endometrial cancer,” Applied Immunohistochemistry and Molecular Morphology, vol. 16, no. 6, pp. 543–547, 2008.
- K. V. R. Reddy and S. S. Mangale, “Integrin receptors: the dynamic modulators of endometrial function,” Tissue and Cell, vol. 35, no. 4, pp. 260–273, 2003.
- P. S. Sullivan, E. L. Maresh, D. B. Seligson et al., “Expression of thyroid transcription factor-1 in normal endometrium is associated with risk of endometrial cancer development,” Modern Pathology, vol. 25, pp. 1140–1148, 2012.
- E. C. Ridgway, C. Longcope, and F. Maloof, “Metabolic clearance and blood production rates of estradiol in hyperthyroidism,” The Journal of Clinical Endocrinology & Metabolism, vol. 41, no. 3, pp. 491–497, 1975.
- B. A. Lessey, A. J. Castelbaum, S. W. Sawin, and J. Sun, “Integrins as markers of uterine receptivity in women with primary unexplained infertility,” Fertility and Sterility, vol. 63, no. 3, pp. 535–542, 1995.
- J. J. Bergh, H. Y. Lin, L. Lansing et al., “Integrin αVβ3 contains a cell surface receptor site for thyroid hormone that is linked to activation of mitogen-activated protein kinase and induction of angiogenesis,” Endocrinology, vol. 146, no. 7, pp. 2864–2871, 2005.
- H. A. Risch, “Hormonal etiology of epithelial ovarian cancer, with a hypothesis concerning the role of androgens and progesterone,” Journal of the National Cancer Institute, vol. 90, no. 23, pp. 1774–1786, 1998.
- R. B. Ness, J. A. Grisso, C. Cottreau et al., “Factors related to inflammation of the ovarian epithelium and risk of ovarian cancer,” Epidemiology, vol. 11, no. 2, pp. 111–117, 2000.
- M. T. Rae, O. Gubbay, A. Kostogiannou, D. Price, H. O. D. Critchley, and S. G. Hillier, “Thyroid hormone signaling in human ovarian surface epithelial cells,” The Journal of Clinical Endocrinology & Metabolism, vol. 92, no. 1, pp. 322–327, 2007.