Chlamydia trachomatis Antibody Testing in Vaginal Mucosal Material versus Blood Samples of Women Attending a Fertility Clinic and an STI Clinic

Table 2

Comparison of the sensitivity, specificity, and agreement between test results of different antibodies in serum and swab with active or past Chlamydia infection or complications thereof, in fertility clinic and STI clinic.

	Sensitivity	Specificity	Kappa-value
Fertility clinic; Probable past Ct infection^#, PID, or tubal pathology reported
Serum-IgG	79%	89%	0.67 (𝑃<0.001)
Swab-IgG	63%	64%	0.23 (𝑃=0.03)
Swab-IgA	29%	98%	0.34 (𝑃<0.001)
Tubal pathology
Serum-IgG	89%	75%	0.36 (𝑃<0.001)
Swab-IgG	56%	57%	0.06 (𝑃=0.47)
Swab-IgA	56%	94%	0.41 (𝑃<0.001)
STI clinic; Active infection*/probable past Ct infection^#
Serum-IgG	87%	95%	0.83 (𝑃<0.001)
Serum-IgA	32%	95%	0.32 (𝑃<0.001)
Swab-IgG	43%	63%	0.06 (𝑃=0.53)
Swab-IgA	38%	90%	0.32 (𝑃<0.001)

∗Active infection: PCR positive at STI clinic.
^#Probable past Chlamydia infection. #: history of STI at STI clinic or reported Chlamydia infection in the past or complications related to chlamydia (PID, tubal pathology) in fertility clinic.