Placenta-Specific Protein 1: A Potential Key to Many Oncofetal-Placental OB/GYN Research Questions

Figure 2

Human PLAC1 gene organization and transcription. (a) The genomic structure of the PLAC1 gene and the location of the two promoters are shown. Noncoding DNA is indicated by the filled boxes while the 3′-most part of the 5′ UTR, the complete coding region, and the 3′ UTR are all contained in exon 6. The distances between the exons are also shown. (b) Transcription factors and suspected transcription influencing factors associated with the two PLAC1 promoters. (c) mRNA transcripts produced by the human PLAC1 gene that have been cloned by the authors. All three transcripts, P1L (ong), P1S (hort), and P2, have been cloned from a single reverse transcription in several instances including both endometrial and ovarian tumors.