Resveratrol, Acetyl-Resveratrol, and Polydatin Exhibit Antigrowth Activity against 3D Cell Aggregates of the SKOV-3 and OVCAR-8 Ovarian Cancer Cell Lines

Figure 3

The effect of resveratrol (a), acetyl-resveratrol (b), and polydatin (c) on the expression of poly(ADP-ribose) polymerase (PARP) which was used as an indicator of apoptosis in SKOV-3 cell aggregates. At higher concentrations resveratrol, acetyl-resveratrol, and polydatin increased the fragmentation of PARP giving a band of 89 kDa which was indicative of apoptosis. At 10 μM resveratrol induced the fragmentation of PARP. Based line expression of PARP at 116 and 89 kDa was observed in controls and low doses of all compounds.

(a)

(b)

(c)