Intensification of Doxorubicin-Related Oxidative Stress in the Heart by Hypothyroidism Is Not Related to the Expression of Cytochrome P450 NADPH-Reductase and Inducible Nitric Oxide Synthase, As Well As Activity of Xanthine Oxidase

<table>Strong positive cytoplasmic immunostaining for inducible nitric oxide synthase (iNOS) in cardiomyocytes. (a) 5DOX/96 h. (b) 5DOX + MET<sub>L</sub>/96 h; (<svg height="11.4375" id="M182" style="vertical-align:-0.51414pt" version="1.1" viewbox="0 0 99.449997 11.4375" width="99.449997" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,11.4375)">
<g transform="translate(72,-62.85)">
<text transform="matrix(1,0,0,-1,-71.95,63.41)">
<tspan style="font-size: 12.50px; " x="0" y="0">D</tspan>
<tspan style="font-size: 12.50px; " x="9.0271664" y="0">a</tspan>
<tspan style="font-size: 12.50px; " x="14.578498" y="0">k</tspan>
<tspan style="font-size: 12.50px; " x="20.567434" y="0">o</tspan>
<tspan style="font-size: 12.50px; " x="26.818935" y="0">E</tspan>
<tspan style="font-size: 12.50px; " x="34.458267" y="0">n</tspan>
<tspan style="font-size: 12.50px; " x="40.322174" y="0">v</tspan>
<tspan style="font-size: 12.50px; " x="46.573673" y="0">i</tspan>
<tspan style="font-size: 12.50px; " x="50.049507" y="0">s</tspan>
<tspan style="font-size: 12.50px; " x="54.913177" y="0">i</tspan>
<tspan style="font-size: 12.50px; " x="58.389011" y="0">o</tspan>
<tspan style="font-size: 12.50px; " x="64.640511" y="0">n</tspan>
<tspan style="font-size: 12.50px; " x="70.892014" y="0">+</tspan>
</text>
</g>
</g>
</svg>/HRP; objective magnification (a) and (b): 20x).</table>

Oxidative Medicine and Cellular Longevity

fig3

Figure 3

Figure 3: Intensification of Doxorubicin-Related Oxidative Stress in the Heart by Hypothyroidism Is Not Related to the Expression of Cytochrome P450 NADPH-Reductase and Inducible Nitric Oxide Synthase, As Well As Activity of Xanthine Oxidase 

Figure 3 | Intensification of Doxorubicin-Related Oxidative Stress in the Heart by Hypothyroidism Is Not Related to the Expression of Cytochrome P450 NADPH-Reductase and Inducible Nitric Oxide Synthase, As Well As Activity of Xanthine Oxidase 