Table 3: Carbonyl group concentration (nmol/mg of of cardiac protein; 𝑋 ± S . D .) in rat cardiac homogenates 4, 48, and 96 h after doxorubicin administration.

Time from DOX injection (h)DOX (mg/kg) or salineMethimazole (%)ANOVA
0.00000.001 (METL)0.025 (METH) 𝑃

42 1 9 . 5 5 ± 5 . 1 2 2 8 . 1 8 ± 6 . 1 1 *,# 4 5 . 4 5 ± 1 6 . 1 5 *,#,†0.0098
5 1 9 . 4 1 ± 9 . 4 1 3 8 . 6 5 ± 1 3 . 4 5 *,# 1 0 3 . 0 8 ± 4 6 . 0 3 *,#,†0.0050
15 5 7 . 5 2 ± 1 6 . 0 5 * 2 0 . 0 8 ± 7 . 5 9 # 7 5 . 7 7 ± 1 4 . 2 5 *,#0.0060

482 1 8 . 9 2 ± 5 . 3 0 2 9 . 4 6 ± 6 . 9 2 *,# 4 2 . 7 5 ± 1 2 . 4 6 *,#0.0098
5 2 1 . 2 9 ± 6 . 6 2 4 0 . 4 3 ± 2 2 . 0 4 *,# 1 0 9 . 9 5 ± 8 4 . 4 8 *,#0.0063
1554.73 ± 1434* 1 4 . 7 0 ± 6 . 5 7 # 1 2 4 . 2 4 ± 6 2 . 8 4 *,#0.0045

962 1 5 . 3 9 ± 4 . 2 4 2 8 . 4 9 ± 1 0 . 6 1 *,# 3 7 . 2 1 ± 6 . 6 7 *,#0.0081
5 1 5 . 0 5 ± 4 . 3 0 1 9 . 5 1 ± 4 . 3 7 # 8 9 . 2 2 ± 4 2 . 4 2 *,#,†0.0052
15 3 9 . 3 0 ± 1 0 . 1 4 * 1 5 . 0 6 ± 4 . 9 8 # 9 1 . 7 6 ± 5 6 . 7 6 *,#,†0.0025
0.9% NaCl 𝟏 𝟕 . 𝟔 𝟖 ± 𝟓 . 𝟗 𝟐 (control) 1 7 . 8 7 ± 3 . 3 5 2 0 . 8 7 ± 4 . 2 9

* 𝑃 < 0 . 0 5 versus control; #DOX + MET versus DOX; DOX + METH + versus DOX + METL.