Table 4: The amount of oxidative damages of DNA (for 106 base pairs; 𝑋 ± S . D .) in rat cardiac homogenates 4, 48, and 96 h after doxorubicin administration.

Time from DOX injection (h)DOX (mg/kg) or salineMethimazole (%)ANOVA
0.00000.001 (METL)0.025 (METH) 𝑃

42 1 . 2 2 ± 0 . 1 4 1 . 1 6 ± 0 . 1 1 1 . 2 3 ± 0 . 1 1 0.4706
5 1 . 5 4 ± 0 . 2 1 * 1 . 2 6 ± 0 . 1 2 * 1 . 6 0 ± 0 . 2 2 *,†0.0478
15 1 . 8 2 ± 0 . 1 7 * 1 . 6 4 ± 0 . 1 7 * 1 . 9 0 ± 0 . 3 1 *0.2645

482 1 . 1 3 ± 0 . 0 5 1 . 1 4 ± 0 . 0 7 1 . 1 2 ± 0 . 0 4 0.8670
5 1 . 2 1 ± 0 . 0 7 * 1 . 1 4 ± 0 . 0 6 1 . 2 9 ± 0 . 0 3 *,†0.0183
15 1 . 5 5 ± 0 . 1 3 * 1 . 3 8 ± 0 . 1 5 * 1 . 6 3 ± 0 . 1 7 *0.0517

962 1 . 1 1 ± 0 . 0 6 1 . 1 0 ± 0 . 0 5 1 . 1 0 ± 0 . 0 4 0.9900
5 1 . 1 5 ± 0 . 3 5 1 . 1 0 ± 0 . 0 3 1 . 2 3 ± 0 . 0 9 *,†0.0271
15 1 . 3 5 ± 0 . 1 3 * 1 . 2 9 ± 0 . 0 8 * 1 . 3 8 ± 0 . 0 6 *0.2645
0.9% NaCl 𝟏 . 𝟏 𝟎 ± 𝟎 . 𝟎 𝟓 (control) 1 . 1 3 ± 0 . 0 6 1 . 1 1 ± 0 . 0 6

* 𝑃 < 0 . 0 5 versus control; DOX + METH versus DOX + METL.