Intensification of Doxorubicin-Related Oxidative Stress in the Heart by Hypothyroidism Is Not Related to the Expression of Cytochrome P450 NADPH-Reductase and Inducible Nitric Oxide Synthase, As Well As Activity of Xanthine Oxidase

Table 4

The amount of oxidative damages of DNA (for 10⁶ base pairs; 𝑋±S.D.) in rat cardiac homogenates 4, 48, and 96 h after doxorubicin administration.

Time from DOX injection (h)	DOX (mg/kg) or saline	Methimazole (%)			ANOVA
		0.0000	0.001 (METL)	0.025 (METH)	𝑃
4	2	1.22±0.14	1.16±0.11	1.23±0.11	0.4706
	5	1.54±0.21^*	1.26±0.12^*	1.60±0.22^*,†	0.0478
	15	1.82±0.17^*	1.64±0.17^*	1.90±0.31^*	0.2645
48	2	1.13±0.05	1.14±0.07	1.12±0.04	0.8670
	5	1.21±0.07^*	1.14±0.06	1.29±0.03^*,†	0.0183
	15	1.55±0.13^*	1.38±0.15^*	1.63±0.17^*	0.0517
96	2	1.11±0.06	1.10±0.05	1.10±0.04	0.9900
	5	1.15±0.35	1.10±0.03	1.23±0.09^*,†	0.0271
	15	1.35±0.13^*	1.29±0.08^*	1.38±0.06^*	0.2645
	0.9% NaCl	𝟏.𝟏𝟎±𝟎.𝟎𝟓 (control)	1.13±0.06	1.11±0.06

^*𝑃<0.05 versus control; ^†DOX + MET_H versus DOX + MET_L.