Table 5: Total glutathione concentration (nmol/g of cardiac sample; 𝑋 ± S . D .) in rat cardiac homogenates 4, 48, and 96 h after doxorubicin administration.

Time from DOX injection (h)DOX (mg/kg) or salineMethimazole (%)ANOVA
0.00000.001 (METL)0.025 (METH) 𝑃

42 3 6 9 . 2 7 ± 2 9 . 4 5 3 5 3 . 0 4 ± 3 0 . 2 4 3 6 3 . 6 8 ± 3 7 . 9 7 0.6505
5 4 0 5 . 8 3 ± 7 7 . 7 6 3 5 6 . 6 6 ± 2 6 . 2 8 3 9 4 . 1 6 ± 3 9 . 1 5 0.3356
15 3 4 8 . 3 3 ± 2 2 . 5 5 4 1 8 . 3 3 ± 5 2 . 5 0 3 6 3 . 3 3 ± 3 9 . 4 6 0.0514

482 3 6 1 . 5 4 ± 4 3 . 7 6 3 9 5 . 5 2 ± 3 1 . 9 2 3 7 8 . 8 5 ± 2 9 . 8 2 0.4449
5 3 5 3 . 3 3 ± 7 0 . 7 3 4 5 4 . 1 6 ± 4 6 . 6 8 *,# 4 5 5 . 8 3 ± 4 1 . 1 0 *,#0.0418
15 3 9 5 . 8 3 ± 6 9 . 5 3 5 6 4 . 1 6 ± 7 2 . 0 8 *,# 4 3 9 . 1 7 ± 1 6 . 8 2 *,#,†0.0080

962 3 3 9 . 1 6 ± 4 3 . 1 6 3 2 8 . 3 3 ± 2 7 . 5 4 3 6 2 . 5 0 ± 3 5 . 8 4 0.2101
5 3 4 0 . 0 0 ± 3 1 . 5 4 4 2 1 . 6 6 ± 4 9 . 0 7 * 3 0 0 . 8 3 ± 6 2 . 0 4 *,#,†0.0081
15 3 2 2 . 9 2 ± 5 5 . 5 4 3 6 7 . 7 1 ± 3 4 . 4 2 3 6 5 . 0 0 ± 3 8 . 1 4 0.3813
0.9% NaCl 𝟑 𝟔 𝟖 . 𝟑 𝟑 ± 𝟑 𝟒 . 𝟒 𝟑 (control) 3 4 2 . 7 1 ± 8 3 . 5 7 3 9 5 . 8 3 ± 2 5 . 6 8

* 𝑃 < 0 . 0 5 versus control; #DOX + MET versus DOX; DOX + METH versus DOX + METL.