Antioxidant Capacity of Flavonoids in Hepatic Microsomes Is not Reflected by Antioxidant Effects In Vivo

Table 1

Abilities of polyphenol aglycones and dα-tocopherol to delay the onset of peroxidation (lag phase) of hepatic microsomal preparations from vitamin E deficient rats.

Compound		Lag phase (min)
	0.1 mM	0.25 mM	0.5 mM
Quercetin	8.7	>20	>20
Kaempferol	7.8	19.8	>20
Myricetin	7.0	12.6	14.3
Apigenin	4.7	4.7	4.8
Catechin	5.8	5.9	6.2
Morin	4.1	7.4	9.6
Galingin	3.3	>20	>20
Fisetin	4.9	15.0	>20
dα-tocopherol	>20	>20	>20

Peroxidation was initiated with an ascorbate/Fe²⁺/ADP complex and estimated by the formation of thiobarbituric acid substances (TBARS) as described in Section 2. Values are means of duplicate determinations.