About this Journal Submit a Manuscript Table of Contents
Oxidative Medicine and Cellular Longevity
Volume 2012 (2012), Article ID 171383, 10 pages
http://dx.doi.org/10.1155/2012/171383
Research Article

Age-Associated Molecular Changes in the Kidney in Aged Mice

Division of Nephrology, Department of Internal Medicine, College of Medicine, Catholic University of Korea, Seoul 137-040, Republic of Korea

Received 14 September 2012; Revised 30 November 2012; Accepted 11 December 2012

Academic Editor: Pinar Atukeren

Copyright © 2012 Ji Hee Lim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. K. H. Campbell and A. M. O’Hare, “Kidney disease in the elderly: update on recent literature,” Current Opinion in Nephrology and Hypertension, vol. 17, no. 3, pp. 298–303, 2008.
  2. A. M. O’Hare, D. Bertentha, K. E. Covinsky, et al., “Mortality risk stratification in chronic kidney disease: one size for all ages?” Journal of the American Society of Nephrology, vol. 17, no. 3, pp. 846–853, 2006.
  3. B. Rogina and S. L. Helfand, “Sir2 mediates longevity in the fly through a pathway related to calorie restriction,” Proceedings of the National Academy of Sciences of the United States of America, vol. 101, no. 45, pp. 15998–16003, 2004.
  4. I. Davies, A. P. Fotheringham, and B. E. Faragher, “Age-associated changes in the kidney of the laboratory mouse,” Age and Ageing, vol. 18, no. 2, pp. 127–133, 1989. View at Scopus
  5. C. Baylis and B. Corman, “The aging kidney: insights from experimental studies,” Journal of the American Society of Nephrology, vol. 9, no. 4, pp. 699–709, 1998. View at Scopus
  6. M. S. Razzaque, “Does renal ageing affect survival?” Ageing Research Reviews, vol. 6, no. 3, pp. 211–222, 2007.
  7. M. S. McLachlan, J. C. Guthrie, C. K. Anderson, and M. J. Fulker, “Vascular and glomerular changes in the ageing kidney,” Journal of Pathology, vol. 121, no. 2, pp. 65–78, 1977. View at Scopus
  8. M. Epsteina and N. K. Hollenbeg, “Age as a determinant of renal sodium conservation in normal man,” Journal of Laboratory and Clinical Medicine, vol. 87, no. 3, pp. 411–417, 1976.
  9. H. Zhang, Y. Li, Y. Fan, et al., “Klotho is a target gene of PPAR-γ,” Kidney International, vol. 74, no. 6, pp. 732–739, 2008.
  10. M. Kaeberlein, M. McVey, and L. Guarente, “The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms,” Genes and Development, vol. 13, no. 19, pp. 2570–2580, 1999. View at Publisher · View at Google Scholar · View at Scopus
  11. H. A. Lim, E. K. Lee, J. M. Kim, et al., “PPARγ activation by baicalin suppresses NF-κB-mediated inflammation in aged rat kidney,” Biogerontology, vol. 13, no. 2, pp. 133–145, 2012.
  12. M. W. Taal, G. M. Chertow, B. M. Brenner, et al., “Brenner & Rector's,” in The Kidney, WB Saunders, Philadelphia, Pa, USA, 9th edition, 2011.
  13. S. Papa and V. P. Skulachev, “Reactive oxygen species, mitochondria, apoptosis and aging,” Molecular and Cellular Biochemistry, vol. 174, no. 1-2, pp. 305–319, 1997. View at Publisher · View at Google Scholar · View at Scopus
  14. K. B. Beckman and B. N. Ames, “The free radical theory of aging matures,” Physiological Reviews, vol. 78, no. 2, pp. 547–581, 1998. View at Scopus
  15. H. W. Chung, J. H. Lim, M. Y. Kim, et al., “High-fat diet-induced renal cell apoptosis and oxidative stress in spontaneously hypertensive rat are ameliorated by fenofibrate through the PPARα-FoxO3α-PGC-1α pathway,” Nephrology Dialysis Transplantation, vol. 27, no. 6, pp. 2213–2225, 2012.
  16. P. Ruiz-Torres, J. Lucio, M. Gonzalez-Rubio, M. Rodríguez-Puyol, and D. Rodríguez-Puyol, “Oxidant/antioxidant balance in isolated glomeruli and cultured mesangial cells,” Free Radical Biology & Medicine, vol. 22, no. 1-2, pp. 49–56, 1997.
  17. J. F. Reckelhoff, V. Kanji, L. C. Racusen et al., “Vitamin E ameliorates enhanced renal lipid peroxidation and accumulation of F2-isoprostanes in aging kidneys,” American Journal of Physiology, vol. 274, no. 3, pp. R767–R774, 1998. View at Scopus
  18. M. Ushio-Fukai, A. M. Zafari, T. Fukui, N. Ishizaka, and K. K. Griendling, “p22(phox) is a critical component of the superoxide-generating NADH/NADPH oxidase system and regulates angiotensin II-induced hypertrophy in vascular smooth muscle cells,” Journal of Biological Chemistry, vol. 271, no. 38, pp. 23317–23321, 1996. View at Publisher · View at Google Scholar · View at Scopus
  19. G. Wolf, F. N. Ziyadeh, R. Schroeder, and R. A. K. Stahl, “Angiotensin II inhibits inducible nitric oxide synthase in tubular MCT cells by a posttranscriptional mechanism,” Journal of the American Society of Nephrology, vol. 8, no. 4, pp. 551–557, 1997. View at Scopus
  20. J. M. Huss, R. P. Kopp, and D. P. Kelly, “Peroxisome proliferator-activated receptor coactivator-1α (PGC-1α) coactivates the cardiac-enriched nuclear receptors estrogen-related receptor-α and -γ: identification of novel Leucine-rich interaction motif within PGC-1α,” Journal of Biological Chemistry, vol. 277, no. 43, pp. 40265–40274, 2002. View at Publisher · View at Google Scholar · View at Scopus
  21. Z. Z. Chong, Y. C. Shang, S. Wang, and K. Maiese, “SIRT1: new avenues of discovery for disorders of oxidative stress,” Expert Opinion on Therapeutic Targets, vol. 16, no. 2, pp. 167–178, 2012.
  22. N. B. Ruderman, X. J. Xu, L. Nelson et al., “AMPK and SIRT1: a long-standing partnership?” American Journal of Physiology, vol. 298, no. 4, pp. E751–E760, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. R. B. Vega, J. M. Huss, and D. P. Kelly, “The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor α in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes,” Molecular and Cellular Biology, vol. 20, no. 5, pp. 1868–1876, 2000. View at Publisher · View at Google Scholar · View at Scopus
  24. Y. X. Wang, C. H. Lee, S. Tiep et al., “Peroxisome-proliferator-activated receptor δ activates fat metabolism to prevent obesity,” Cell, vol. 113, no. 2, pp. 159–170, 2003. View at Publisher · View at Google Scholar · View at Scopus
  25. J. A. Baur, K. J. Pearson, N. L. Price, et al., “Resveratrol improves health and survival of mice on a high-calorie diet,” Nature, vol. 444, no. 7117, pp. 337–342, 2006.
  26. S. N. Schreiber, D. Knutti, K. Brogli, T. Uhlmann, and A. Kralli, “The transcriptional coactivator PGC-1 regulates the expression and activity of the orphan nuclear receptor estrogen-related receptor α (ERRα),” Journal of Biological Chemistry, vol. 278, no. 11, pp. 9013–9018, 2003. View at Publisher · View at Google Scholar · View at Scopus
  27. L. F. Michael, Z. Wu, R. B. Cheatham et al., “Restoration of insulin-sensitive glucose transporter (GLUT4) gene expression in muscle cells by the transcriptional coactivator PGC-1,” Proceedings of the National Academy of Sciences of the United States of America, vol. 98, no. 7, pp. 3820–3825, 2001. View at Publisher · View at Google Scholar · View at Scopus
  28. P. Puigserver, J. Rhee, and J. Donocan, “Insulin-required hepatic gluconeogensis through FOXO1-PGC-1α interaction,” Nature, vol. 423, no. 6939, pp. 550–555, 2003.
  29. Y. Tanaka, S. Kume, S. Araki, et al., “Fenofibrate, a PPARα agonist, has renoprotective effects in mice by enhancing renal lipolysis,” Kidney International, vol. 71, no. 8, pp. 871–882, 2011.
  30. S. N. Schreiber, R. Emter, M. B. Hock, et al., “The estrogen-related receptor α (ERRα) functions in PPARγ coactivator 1α (PGC-1α)-induced mitochondrial biogenesis,” Proceedings of the National Academy of Sciences of the United States of America, vol. 101, no. 17, pp. 6472–6477, 2004.
  31. J. M. Huss, I. Pineda Torra, B. Staels, V. Giguère, and D. P. Kelly, “Estrogen-related receptor α directs peroxisome proliferator-activated receptor α signaling in the transcriptional control of energy metabolism in cardiac and skeletal muscle,” Molecular and Cellular Biology, vol. 24, no. 20, pp. 9079–9091, 2004. View at Publisher · View at Google Scholar · View at Scopus
  32. J. C. Carrier, G. Deblois, C. Champigny, E. Levy, and V. Giguère, “Estrogen-related receptor α (ERRα) is a transcriptional regulator of apolipoprotein A-IV and controls lipid handling in the intestine,” Journal of Biological Chemistry, vol. 279, no. 50, pp. 52052–52058, 2004. View at Publisher · View at Google Scholar · View at Scopus
  33. J. A. Villena, M. B. Hock, W. Y. Chang, J. E. Barcas, V. Giguère, and A. Kralli, “Orphan nuclear receptor estrogen-related receptor alpha is essential for adaptive thermogenesis,” Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 4, pp. 1418–1423, 2007.
  34. M. Kuro-o, “Klotho and the aging process,” Korean Journal of Internal Medicine, vol. 26, no. 2, pp. 113–122, 2011. View at Publisher · View at Google Scholar · View at Scopus
  35. G. Maltese and J. Karalliedde, “The putative role of the antiageing protein klotho in cardiovascular and renal disease,” International Journal of Hypertension, vol. 2012, Article ID 757469, 5 pages, 2012. View at Publisher · View at Google Scholar
  36. S. M. Rangwala, X. Li, L. Lindsley, et al., “Estrogen-related receptor alpha is essential for the expression of antioxidant protection genes and mitochondrial function,” Biochemical and Biophysical Research Communications, vol. 357, no. 1, pp. 231–236, 2007.
  37. K. Goya, S. Sumitani, X. Xu, et al., “Peroxisome proliferator-activated receptor α agonists increase nitric oxide synthase expression in vascular endothelial cells,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 24, no. 4, pp. 658–663, 2004.
  38. I. Inoue, S. I. Goto, T. Matsunaga et al., “The ligands/activators for peroxisome proliferator-activated receptor α (PPARα) and PPARγ increase Cu2+,Zn2+-superoxide dismutase and decrease p22phox message expressions in primary endothelial cells,” Metabolism, vol. 50, no. 1, pp. 3–11, 2001. View at Publisher · View at Google Scholar · View at Scopus
  39. S. Chung and C. W. Park, “Role of peroxisome proliferator-activated receptor α in diabetic nephropathy,” Diabetes & Metabolism, vol. 35, no. 4, pp. 327–336, 2011.