Flavonoids Inhibit the Respiratory Burst of Neutrophils in Mammals

Figure 1

Schematic diagram showing the possible mechanisms underlying the inhibition of ROS production by neutrophils using flavonoids. The signaling molecules generally employed in mediating the activation of PLD are shown (some additional signaling molecules in these pathways are omitted). Blunt lines indicate the possible sites of the action of flavonoids (the blockade of PKC, Arf, and RhoA, as well as the scavenging of ROS generated by neutrophils).