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Oxidative Medicine and Cellular Longevity
Volume 2012 (2012), Article ID 185867, 14 pages
The Antioxidant Effects of a Polyphenol-Rich Grape Pomace Extract In Vitro Do Not Correspond In Vivo Using Exercise as an Oxidant Stimulus
1Department of Biochemistry and Biotechnology, University of Thessaly, 41221 Larissa, Greece
2Department of Physical Education and Sports Science at Serres, Aristotle University of Thessaloniki, Agios Ioannis, 62110 Serres, Greece
3Division of Pharmacognosy and Natural Products Chemistry, Faculty of Pharmacy, University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece
Received 22 January 2012; Accepted 26 March 2012
Academic Editor: Chad M. Kerksick
Copyright © 2012 Aristidis S. Veskoukis et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- L. L. Ji, “Antioxidant signaling in skeletal muscle: a brief review,” Experimental Gerontology, vol. 42, no. 7, pp. 582–593, 2007.
- M. C. Gomez-Cabrera, C. Borrás, F. V. Pallardo, J. Sastre, L. L. Ji, and J. Viña, “Decreasing xanthine oxidase-mediated oxidative stress prevents useful cellular adaptations to exercise in rats,” Journal of Physiology, vol. 567, no. 1, pp. 113–120, 2005.
- M. G. Nikolaidis, V. Paschalis, G. Giakas et al., “Decreased blood oxidative stress after repeated muscle-damaging exercise,” Medicine and Science in Sports and Exercise, vol. 39, no. 7, pp. 1080–1089, 2007.
- J. L. Betters, D. S. Criswell, R. A. Shanely et al., “Trolox attenuates mechanical ventilation-induced diaphragmatic dysfunction and proteolysis,” American Journal of Respiratory and Critical Care Medicine, vol. 170, no. 11, pp. 1179–1184, 2004.
- A. S. Veskoukis, M. G. Nikolaidis, A. Kyparos et al., “Effects of xanthine oxidase inhibition on oxidative stress and swimming performance in rats,” Applied Physiology, Nutrition and Metabolism, vol. 33, no. 6, pp. 1140–1154, 2008.
- Y. Michailidis, A. Z. Jamurtas, M. G. Nikolaidis et al., “Sampling time is crucial for measurement of aerobic exercise-induced oxidative stress,” Medicine and Science in Sports and Exercise, vol. 39, no. 7, pp. 1107–1113, 2007.
- M. G. Nikolaidis, A. Z. Jamurtas, V. Paschalis et al., “Exercise-induced oxidative stress in G6PD-deficient individuals,” Medicine and Science in Sports and Exercise, vol. 38, no. 8, pp. 1443–1450, 2006.
- J. M. McCord and I. Fridovich, “The reduction of cytochrome c by milk xanthine oxidase,” Journal of Biological Chemistry, vol. 243, no. 21, pp. 5753–5760, 1968.
- D. D. M. Wayner, G. W. Burton, K. U. Ingold, L. R. C. Barclay, and S. J. Locke, “The relative contributions of vitamin E, urate, ascorbate and proteins to the total peroxyl radical-trapping antioxidant activity of human blood plasma,” Biochimica Biophysica Acta, vol. 924, no. 3, pp. 408–419, 1987.
- B. Halliwell and J. Gutteridge, Free Radicals in Biology and Medicine, Oxford University Press, New York, NY, USA, 2007.
- B. Fauconneau, P. Waffo-Teguo, F. Huguet, L. Barrier, A. Decendit, and J. M. Merillon, “Comparative study of radical scavenger and antioxidant properties of phenolic compounds from Vitis vinifera cell cultures using in vitro tests,” Life Sciences, vol. 61, no. 21, pp. 2103–2110, 1997.
- D. Bagchi, M. Bagchi, S. J. Stohs et al., “Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention,” Toxicology, vol. 148, no. 2-3, pp. 187–197, 2000.
- K. N. C. Murthy, R. P. Singh, and G. K. Jayaprakasha, “Antioxidant activities of grape (Vitis vinifera) pomace extracts,” Journal of Agricultural and Food Chemistry, vol. 40, no. 21, pp. 941–947, 2002.
- C. W. Beninger and G. L. Hosfield, “Antioxidant activity of extracts, condensed tannin fractions, and pure flavonoids from Phaseolus vulgaris L. Seed coat color genotypes,” Journal of Agricultural and Food Chemistry, vol. 51, no. 27, pp. 7879–7883, 2003.
- C. Manna, V. Migliardi, P. Golino et al., “Oleuropein prevents oxidative myocardial injury induced by ischemia and reperfusion,” Journal of Nutritional Biochemistry, vol. 15, no. 8, pp. 461–466, 2004.
- D. Heimler, P. Vignolini, M. G. Dini, and A. Romani, “Rapid tests to assess the antioxidant activity of Phaseolus vulgaris L. dry beans,” Journal of Agricultural and Food Chemistry, vol. 53, no. 8, pp. 3053–3056, 2005.
- S. H. Kim, K. S. Park, M. J. Chang, and J. H. Sung, “Effects of Panax ginseng extract on exercise-induced oxidative stress,” Journal of Sports Medicine and Physical Fitness, vol. 45, no. 2, pp. 178–182, 2005.
- J. Voces, A. I. Alvarez, L. Vila, A. Ferrando, C. Cabral De Oliveira, and J. G. Prieto, “Effects of administration of the standardized Panax ginseng extract G115 on hepatic antioxidant function after exhaustive exercise,” Comparative Biochemistry and Physiology C, vol. 123, no. 2, pp. 175–184, 1999.
- J. Voces, A. C. Cabral de Oliveira, J. G. Prieto et al., “Ginseng administration protects skeletal msucle from oxidative stress induced by acute exercise in rats,” Brazilian Journal of Medical and Biological Research, vol. 37, no. 12, pp. 1863–1871, 2004.
- A. Skarpanska-Stejnborn, P. Basta, and L. Pilaczynska-Szczesniak, “The influence of supplementation with black currant (Ribes nigrum) extract on selected prooxidative-antioxidative balance in rowers,” Studies in Physical Culture and Tourism, vol. 13, pp. 51–58, 2006.
- A. Skarpañska-Stejnborn, L. Pilaczynska-Szczesniak, P. Basta, E. Deskur-Smielecka, and M. Horoszkiewicz-Hassan, “The influence of supplementation with artichoke (Cynara scolymus L.) extract on selected redox parameters in rowers,” International Journal of Sport Nutrition and Exercise Metabolism, vol. 18, no. 3, pp. 313–327, 2008.
- A. Skarpanska-Stejnborn, L. Pilaczynska-Szczesniak, P. Basta, and E. Deskur-Smielecka, “The influence of supplementation with Rhodiola rosea L. extract on Selected redox parameters in professional rowers,” International Journal of Sport Nutrition and Exercise Metabolism, vol. 19, no. 2, pp. 186–199, 2009.
- C. Manach, G. Williamson, C. Morand, A. Scalbert, and C. Rémésy, “Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies,” The American Journal of Clinical Nutrition, vol. 81, no. 1, supplement, pp. 230S–42S, 2005.
- D. Stagos, S. Kouris, and D. Kouretas, “Plant phenolics protect from bleomycin-induced oxidative stress and mutagenicity in Salmonella typhimurium TA102,” Anticancer Research, vol. 24, no. 2 B, pp. 743–745, 2004.
- D. Stagos, G. Kazantzoglou, P. Magiatis, S. Mitaku, K. Anagnostopoulos, and D. Kouretas, “Effects of plant phenolics and grape extracts from Greek varieties of Vitis vinifera on Mitomycin C and topoisomerase I-induced nicking of DNA,” International Journal of Molecular Medicine, vol. 15, no. 6, pp. 1013–1022, 2005.
- D. Stagos, C. Spanou, M. Margariti et al., “Cytogenetic effects of grape extracts (Vitis vinifera) and polyphenols on mitomycin C-induced sister chromatid exchanges (SCEs) in human blood lymphocytes,” Journal of Agricultural and Food Chemistry, vol. 55, no. 13, pp. 5246–5252, 2007.
- V. L. Singleton, R. Orthofer, and R. M. Lamuela-Raventós, “Analysis of total phenols and other oxidation substrates and antioxidants by means of folin-ciocalteu reagent,” Methods in Enzymology, vol. 299, pp. 152–178, 1999.
- W. Brand-Williams, M. E. Cuvelier, and C. Berset, “Use of a free radical method to evaluate antioxidant activity,” Lebensm Wiss Technology, vol. 28, no. 1, pp. 25–30, 1995.
- A. Cano, J. Hernández-Ruíz, F. García-Cánovas, and M. Acosta, “An end-point method for estimation of the total antioxidant activity in plant material,” Phytochemical Analysis, vol. 9, no. 4, pp. 196–202, 1998.
- S. T. Chang, J. H. Wu, S. Y. Wang, P. L. Kang, N. S. Yang, and L. F. Shyur, “Antioxidant activity of extracts from acacia confusa bark and heartwood,” Journal of Agricultural and Food Chemistry, vol. 49, no. 7, pp. 3420–3424, 2001.
- Y. S. Keum, K. K. Park, J. M. Lee et al., “Antioxidant and anti-tumor promoting activities of the methanol extract of heat-processed ginseng,” Cancer Letters, vol. 150, no. 1, pp. 41–48, 2000.
- A. Ferrando, L. Vila, J. A. Voces, A. C. Cabral, A. I. Alvarez, and J. G. Prieto, “Effects of a standardized Panax ginseng extract on the skeletal muscle of the rat: a comparative study in animals at rest and under exercise,” Planta Medica, vol. 65, no. 3, pp. 239–244, 1999.
- J. Komulainen, T. E. S. Takala, and V. Vihko, “Does increased serum creatine kinase activity reflect exercise-induced muscle damage in rats?” International Journal of Sports Medicine, vol. 16, no. 5, pp. 150–154, 1995.
- A. S. Veskoukis, D. Kouretas, and G. I. Panoutsopoulos, “Substrate specificity of guinea pig liver aldehyde oxidase and bovine milk xanthine oxidase for methyl- and nitrobenzaldehydes,” European Journal of Drug Metabolism and Pharmacokinetics, vol. 31, no. 1, pp. 11–16, 2006.
- S. Renaud and M. de Lorgeril, “Wine, alcohol, platelets, and the French paradox for coronary heart disease,” The Lancet, vol. 339, no. 8808, pp. 1523–1526, 1992.
- R. P. Singh, A. K. Tyagi, S. Dhanalakshmi, R. Agarwal, and C. Agarwal, “Grape seed extract inhibits advanced human prostate tumor growth and angiogenesis and upregulates insulin-like growth factor binding protein-3,” International Journal of Cancer, vol. 108, no. 5, pp. 733–740, 2004.
- G. J. Soleas, E. P. Diamandis, and D. M. Goldberg, “Wine as a biological fluid: history, production, and role in disease prevention,” Journal of Clinical Laboratory Analysis, vol. 11, no. 5, pp. 287–313, 1997.
- N. Cotelle, “Role of flavonoids in oxidative stress,” Current Topics in Medicinal Chemistry, vol. 1, no. 6, pp. 569–590, 2001.
- B. Halliwell, “Dietary polyphenols: good, bad, or indifferent for your health?” Cardiovascular Research, vol. 73, no. 2, pp. 341–347, 2007.
- C. Mylonas and D. Kouretas, “Lipid peroxidation and tissue damage,” In Vivo, vol. 13, no. 3, pp. 295–309, 1999.
- P. Lim, G. E. Wuenschell, V. Holland et al., “Peroxyl radical mediated oxidative DNA base damage: implications for lipid peroxidation induced mutagenesis,” Biochemistry, vol. 43, no. 49, pp. 15339–15348, 2004.
- J. Cadet, T. Delatour, T. Douki et al., “Hydroxyl radicals and DNA base damage,” Mutation Research, vol. 424, no. 1-2, pp. 9–21, 1999.
- H. M. Alessio, A. E. Hagerman, B. K. Fulkerson, J. Ambrose, R. E. Rice, and R. L. Wiley, “Generation of reactive oxygen species after exhaustive aerobic and isometric exercise,” Medicine and Science in Sports and Exercise, vol. 32, no. 9, pp. 1576–1581, 2000.
- E. R. Stadtman and R. L. Levine, “Protein oxidation,” Annals of the New York Academy of Sciences, vol. 899, pp. 191–208, 2000.
- T. You, A. H. Goldfarb, R. J. Bloomer, L. Nguyen, X. Sha, and M. J. McKenzie, “Oxidative stress response in normal and antioxidant supplemented rats to a downhill run: changes in blood and skeletal muscles,” Canadian Journal of Applied Physiology, vol. 30, no. 6, pp. 677–689, 2005.
- R. S. Ajmani, J. L. Fleg, A. A. Demehin et al., “Oxidative stress and hemorheological changes induced by acute treadmill exercise,” Clinical Hemorheology and Microcirculation, vol. 28, no. 1, pp. 29–40, 2003.
- C. Spanou, A. S. Veskoukis, S. Dimitrios et al., “Effects of grape extracts on the in vitro activity of enzymes involved in oxidative stress regulation,” In Vivo, vol. 25, no. 4, pp. 657–662, 2011.
- F. B. Paula, C. M. Gouvêa, P. P. Alfredo, and I. Salgado, “Protective action of a hexane crude extract of Pterodon emarginatus fruits against oxidative and nitrosative stress induced by acute exercise in rats,” BMC Complementary and Alternative Medicine, vol. 5, article 17, 2005.
- F. Yu, S. Lu, F. Yu et al., “Protective effects of polysaccharide from Euphorbia kansui (Euphorbiaceae) on the swimming exercise-induced oxidative stress in mice,” Canadian Journal of Physiology and Pharmacology, vol. 84, no. 10, pp. 1071–1079, 2006.
- A. J. Niu, J. M. Wu, D. H. Yu, and R. Wang, “Protective effect of Lycium barbarum polysaccharides on oxidative damage in skeletal muscle of exhaustive exercise rats,” International Journal of Biological Macromolecules, vol. 42, no. 5, pp. 447–449, 2008.
- F. Puiggròs, E. Sala, M. Vaque et al., “In vivo, in vitro, and in silico studies of CU/ZN-superoxide dismutase regulation by molecules in grape seed procyanidin extract,” Journal of Agricultural and Food Chemistry, vol. 57, no. 9, pp. 3934–3942, 2009.
- E. J. Cho, Y. A. Lee, H. Y. Hye, and T. Yokozawa, “Protective effects of broccoli (Brassica oleracea) against oxidative damage in vitro and in vivo,” Journal of Nutritional Science and Vitaminology, vol. 52, no. 6, pp. 437–444, 2006.
- H. S. Lee, H. W. Nam, H. K. Kyoung, H. Lee, W. Jun, and K. W. Lee, “Antioxidant effects of aqueous extract of Terminalia chebulain Vivo and in Vitro,” Biological and Pharmaceutical Bulletin, vol. 28, no. 9, pp. 1639–1644, 2005.
- G. F. Shi, L. J. An, B. Jiang, S. Guan, and Y. M. Bao, “Alpinia protocatechuic acid protects against oxidative damage in vitro and reduces oxidative stress in vivo,” Neuroscience Letters, vol. 403, no. 3, pp. 206–210, 2006.
- A. Cherubini, M. F. Beal, and B. Frei, “Black tea increases the resistance of human plasma to lipid peroxidation in vitro, but not ex vivo,” Free Radical Biology and Medicine, vol. 27, no. 3-4, pp. 381–387, 1999.
- S. B. Lotito and B. Frei, “Relevance of apple polyphenols as antioxidants in human plasma: contrasting in vitro and in vivo effects,” Free Radical Biology and Medicine, vol. 36, no. 2, pp. 201–211, 2004.
- B. Halliwell, “Are polyphenols antioxidants or pro-oxidants? What do we learn from cell culture and in vivo studies?” Archives of Biochemistry and Biophysics, vol. 476, no. 2, pp. 107–112, 2008.
- M. S. Fernandez-Panchon, D. Villano, A. M. Troncoso, and M. C. Garcia-Parrilla, “Antioxidant activity of phenolic compounds: from in vitro results to in vivo evidence,” Critical Reviews in Food Science and Nutrition, vol. 48, no. 7, pp. 649–671, 2008.
- M. Shirai, Y. Kawai, R. Yamanishi, T. Kinoshita, H. Chuman, and J. Terao, “Effect of a conjugated quercetin metabolite, quercetin 3-glucuronide, on lipid hydroperoxide-dependent formation of reactive oxygen species in differentiated PC-12 cells,” Free Radical Research, vol. 40, no. 10, pp. 1047–1053, 2006.
- J. D. Lawrence, R. C. Bower, W. P. Riehl, and J. L. Smith, “Effects of α tocopherol acetate on the swimming endurance of trained swimmers,” American Journal of Clinical Nutrition, vol. 28, no. 3, pp. 205–208, 1975.
- S. Sumida, K. Tanaka, H. Kitao, and F. Nakadomo, “Exercise-induced lipid peroxidation and leakage of enzymes before and after vitamin E supplementation,” International Journal of Biochemistry, vol. 21, no. 8, pp. 835–838, 1989.
- I. P. Snider, T. L. Bazzarre, S. D. Murdoch, and A. Goldfarb, “Effects of coenzyme athletic performance system as an ergogenic aid on endurance performance to exhaustion,” International Journal of Sport Nutrition, vol. 2, no. 3, pp. 272–286, 1992.
- L. Rokitzki, E. Logemann, A. N. Sagredos, M. Murphy, W. Wetzel-Rothl, and J. Keul, “Lipid peroxidation and antioxidative vitamins under extreme endurance stress,” Acta Physiologica Scandinavica, vol. 150, no. 5, pp. 149–158, 1994.
- S. K. Powers and K. Hamilton, “Antioxidants and exercise,” Clinics in Sports Medicine, vol. 18, no. 3, pp. 525–536, 1999.
- H. J. Engels and J. C. Wirth, “No ergogenic effects of ginseng (Panax ginseng C.A. Meyer) during graded maximal aerobic exercise,” Journal of the American Dietetic Association, vol. 97, no. 10, pp. 1110–1115, 1997.
- J. K. Lang, K. Gohil, L. Packer, and R. F. Burk, “Selenium deficiency, endurance exercise capacity, and antioxidant status in rats,” Journal of Applied Physiology, vol. 63, no. 6, pp. 2532–2535, 1987.
- M. B. Reid, D. S. Stokic, S. M. Koch, F. A. Khawli, and A. A. Leis, “N-acetylcysteine inhibits muscle fatigue in humans,” Journal of Clinical Investigation, vol. 94, no. 6, pp. 2468–2474, 1994.
- S. P. Lee, G. Y. Mar, and L. T. Ng, “Effects of tocotrienol-rich fraction on exercise endurance capacity and oxidative stress in forced swimming rats,” European Journal of Applied Physiology, vol. 107, no. 5, pp. 587–595, 2009.
- G. P. Novelli, G. Bracciotti, and S. Falsini, “Spin-trappers and vitamin E prolong endurance to muscle fatigue in mice,” Free Radical Biology and Medicine, vol. 8, no. 1, pp. 9–13, 1990.
- Y. You, K. Kim, H. Heo et al., “Stimulatory effects of Pseudosasa japonica leaves on exercise performance,” Bioscience, Biotechnology and Biochemistry, vol. 70, no. 10, pp. 2532–2535, 2006.
- T. Murase, S. Haramizu, A. Shimotoyodome, A. Nagasawa, and I. Tokimitsu, “Green tea extract improves endurance capacity and increases muscle lipid oxidation in mice,” American Journal of Physiology, vol. 288, no. 3, pp. R708–R715, 2005.
- R. J. Marshall, K. C. Scott, R. C. Hill et al., “Supplemental vitamin C appears to slow racing greyhounds,” Journal of Nutrition, vol. 132, no. 6, pp. 1616S–1621S, 2002.