- About this Journal ·
- Abstracting and Indexing ·
- Aims and Scope ·
- Annual Issues ·
- Article Processing Charges ·
- Author Guidelines ·
- Bibliographic Information ·
- Citations to this Journal ·
- Contact Information ·
- Editorial Board ·
- Editorial Workflow ·
- Free eTOC Alerts ·
- Publication Ethics ·
- Recently Accepted Articles ·
- Reviewers Acknowledgment ·
- Submit a Manuscript ·
- Subscription Information ·
- Table of Contents
Oxidative Medicine and Cellular Longevity
Volume 2012 (2012), Article ID 217594, 9 pages
Centrosome Aberrations Associated with Cellular Senescence and p53 Localization at Supernumerary Centrosomes
Division of Morphological Science, Biomedical Research Center, Saitama Medical University, 38 Morohongo, Moroyama, Iruma, Saitama 350-0495, Japan
Received 28 May 2012; Revised 27 August 2012; Accepted 11 September 2012
Academic Editor: William C. Burhans
Copyright © 2012 Susumu Ohshima. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- A. Krämer, S. Schweizer, K. Neben et al., “Centrosome aberrations as a possible mechanism for chromosomal instability in non-Hodgkin's lymphoma,” Leukemia, vol. 17, no. 11, pp. 2207–2213, 2003.
- G. A. Pihan, J. Wallace, Y. Zhou, and S. J. Doxsey, “Centrosome abnormalities and chromosome instability occur together in pre-invasive carcinomas,” Cancer Research, vol. 63, no. 6, pp. 1398–1404, 2003.
- K. Fukasawa, “Centrosome amplification, chromosome instability and cancer development,” Cancer Letters, vol. 230, no. 1, pp. 6–19, 2005.
- M. Giehl, A. Fabarius, O. Frank et al., “Centrosome aberrations in chronic myeloid leukemia correlate with stage of disease and chromosomal instability,” Leukemia, vol. 19, no. 7, pp. 1192–1197, 2005.
- E. A. Nigg, “Origins and consequences of centrosome aberrations in human cancers,” International Journal of Cancer, vol. 119, no. 12, pp. 2717–2723, 2006.
- M. A. Ko, C. O. Rosario, J. W. Hudson et al., “Plk4 haploinsufficiency causes mitotic infidelity and carcinogenesis,” Nature Genetics, vol. 37, no. 8, pp. 883–888, 2005.
- R. Basto, K. Brunk, T. Vinadogrova et al., “Centrosome amplification can initiate tumorigenesis in flies,” Cell, vol. 133, no. 6, pp. 1032–1042, 2008.
- O. C. M. Sibon, A. Kelkar, W. Lemstra, and W. E. Theurkauf, “DNA-replication/DNA-damage-dependent centrosome inactivation in Drosophila embryos,” Nature Cell Biology, vol. 2, no. 2, pp. 90–95, 2000.
- H. M. J. Hut, W. Lemstra, E. H. Blaauw, G. W. A. Van Cappellen, H. H. Kampinga, and O. C. M. Sibon, “Centrosomes split in the presence of impaired DNA integrity during mitosis,” Molecular Biology of the Cell, vol. 14, no. 5, pp. 1993–2004, 2003.
- O. C. M. Sibon, “Centrosomes as DNA damage regulators,” Nature Genetics, vol. 34, no. 1, pp. 6–7, 2003.
- H. Dodson, E. Bourke, L. J. Jeffers et al., “Centrosome amplification induced by DNA damage occurs during a prolonged G2 phase and involves ATM,” EMBO Journal, vol. 23, no. 19, pp. 3864–3873, 2004.
- N. Sato, K. Mizumoto, M. Nakamura et al., “A possible role for centrosome overduplication in radiation-induced cell death,” Oncogene, vol. 19, no. 46, pp. 5281–5290, 2000.
- K. Kawamura, N. Morita, C. Domiki et al., “Induction of centrosome amplification in p53 siRNA-treated human fibroblast cells by radiation exposure,” Cancer Science, vol. 97, no. 4, pp. 252–258, 2006.
- H. Löffler, T. Bochtler, B. Fritz et al., “DNA damage-induced accumulation of centrosomal Chk1 contributes to its checkpoint function,” Cell Cycle, vol. 6, no. 20, pp. 2541–2548, 2007.
- S. Ohshima and A. Seyama, “Cellular aging and centrosome aberrations,” Annals of the New York Academy of Sciences, vol. 1197, pp. 108–117, 2010.
- E. Oricchio, C. Saladino, S. Iacovelli, S. Soddu, and E. Cundari, “ATM is activated by default in mitosis, localizes at centrosomes and monitors mitotic spindle integrity,” Cell Cycle, vol. 5, no. 1, pp. 88–92, 2006.
- K. Shinmura, R. A. Bennett, P. Tarapore, and K. Fukasawa, “Direct evidence for the role of centrosomally localized p53 in the regulation of centrosome duplication,” Oncogene, vol. 26, no. 20, pp. 2939–2944, 2007.
- S. Zhang, P. Hemmerich, and F. Grosse, “Centrosomal localization of DNA damage checkpoint proteins,” Journal of Cellular Biochemistry, vol. 101, no. 2, pp. 451–465, 2007.
- M. Shimada and K. Komatsu, “Emerging connection between centrosome and DNA repair machinery,” Journal of Radiation Research, vol. 50, no. 4, pp. 295–301, 2009.
- A. Tritarelli, E. Oricchio, M. Ciciarello et al., “p53 localization at centrosomes during mitosis and postmitotic checkpoint are ATM-dependent and require Serine 15 phosphorylation,” Molecular Biology of the Cell, vol. 15, no. 8, pp. 3751–3757, 2004.
- B. A. Bonsing, W. E. Corver, M. C. B. Gorsira et al., “Specificity of seven monoclonal antibodies against p53 evaluated with western blotting, immunohistochemistry, confocal laser scanning microscopy, and flow cytometry,” Cytometry, vol. 28, no. 1, pp. 11–24, 1997.
- I. Ben-Porath and R. A. Weinberg, “When cells get stressed: an integrative view of cellular senescence,” Journal of Clinical Investigation, vol. 113, no. 1, pp. 8–13, 2004.
- D. B. Lombard, K. F. Chua, R. Mostoslavsky, S. Franco, M. Gostissa, and F. W. Alt, “DNA repair, genome stability, and aging,” Cell, vol. 120, no. 4, pp. 497–512, 2005.
- J.-H. Chen, C. N. Hales, and S. E. Ozanne, “DNA damage, cellular senescence and organismal ageing: Causal or correlative?” Nucleic Acids Research, vol. 35, no. 22, pp. 7417–7428, 2007.
- H. Takai, A. Smogorzewska, and T. De Lange, “DNA damage foci at dysfunctional telomeres,” Current Biology, vol. 13, no. 17, pp. 1549–1556, 2003.
- R. Di Micco, M. Fumagalli, A. Cicalese et al., “Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication,” Nature, vol. 444, no. 7119, pp. 638–642, 2006.
- Z. Storchova and D. Pellman, “From polyploidy to aneuploidy, genome instability and cancer,” Nature Reviews Molecular Cell Biology, vol. 5, no. 1, pp. 45–54, 2004.
- S. Ohshima and A. Seyama, “Formation of bipolar spindles with two centrosomes in tetraploid cells established from normal human fibroblasts,” Human Cell, vol. 25, no. 3, pp. 78–85, 2012.
- R. Kuriyama, Y. Terada, K. S. Lee, and C. L. C. Wang, “Centrosome replication in hydroxyurea-arrested CHO cells expressing GFP-tagged centrin 2,” Journal of Cell Science, vol. 120, no. 14, pp. 2444–2453, 2007.
- S. L. Prosser, K. R. Straatman, and A. M. Fry, “Molecular dissection of the centrosome overduplication pathway in S-phase-arrested cells,” Molecular and Cellular Biology, vol. 29, no. 7, pp. 1760–1773, 2009.
- V. B. Morris, J. Brammall, J. Noble, and R. Reddel, “p53 Localizes to the centrosomes and spindles of mitotic cells in the embryonic chick epiblast, human cell lines, and a human primary culture: an immunofluorescence study,” Experimental Cell Research, vol. 256, no. 1, pp. 122–130, 2000.
- P. Tarapore, Y. Tokuyama, H. F. Horn, and K. Fukasawa, “Difference in the centrosome duplication regulatory activity among p53 'hot spot' mutants: potential role of Ser 315 phosphorylation-dependent centrosome binding of p53,” Oncogene, vol. 20, no. 47, pp. 6851–6863, 2001.
- T. Caspari, “Checkpoints: how to activate p53,” Current Biology, vol. 10, no. 8, pp. R315–R317, 2000.
- J.-P. Kruse and W. Gu, “Modes of p53 Regulation,” Cell, vol. 137, no. 4, pp. 609–622, 2009.
- M. Ciciarello, R. Mangiacasale, M. Casenghi et al., “p53 displacement from centrosomes and p53-mediated G1 arrest following transient inhibition of the mitotic spindle,” Journal of Biological Chemistry, vol. 276, no. 22, pp. 19205–19213, 2001.
- C. C. Ho, P. M. Hau, M. Marxer, and R. Y. Poon, “The requirement of p53 for maintaining chromosomal stability during tetraploidization,” Oncotarget, vol. 1, no. 7, pp. 583–595, 2010.
- Q. Yi, X. Zhao, Y. Huang et al., “P53 dependent centrosome clustering prevents multipolar mitosis in tetraploid cells,” PLoS One, vol. 6, no. 11, Article ID Article numbere27304, 2011.
- T. Oikawa, M. Okuda, Z. Ma et al., “Transcriptional control of BubR1 by p53 and suppression of centrosome amplification by BubR1,” Molecular and Cellular Biology, vol. 25, no. 10, pp. 4046–4061, 2005.
- H. Löffler, J. Lukas, J. Bartek, and A. Krämer, “Structure meets function—centrosomes, genome maintenance and the DNA damage response,” Experimental Cell Research, vol. 312, no. 14, pp. 2633–2640, 2006.
- A. R. Barr and F. Gergely, “Aurora-A: the maker and breaker of spindle poles,” Journal of Cell Science, vol. 120, no. 17, pp. 2987–2996, 2007.
- H. Schatten, “The mammalian centrosome and its functional significance,” Histochemistry and Cell Biology, vol. 129, no. 6, pp. 667–686, 2008.
- Y. Wang, P. Ji, J. Liu, R. R. Broaddus, F. Xue, and W. Zhang, “Centrosome-associated regulators of the G2/M checkpoint as targets for cancer therapy,” Molecular Cancer, vol. 8, article no. 8, 2009.
- D. Zyss and F. Gergely, “Centrosome function in cancer: guilty or innocent?” Trends in Cell Biology, vol. 19, no. 7, pp. 334–346, 2009.
- L. Lentini, V. Barra, T. Schillaci, and A. Di Leonardo, “MAD2 depletion triggers premature cellular senescence in human primary fibroblasts by activating a P53 pathway preventing aneuploid cells propagation,” Journal of Cellular Physiology, vol. 227, no. 9, pp. 3324–3332, 2012.
- S. Schmidt, L. Schneider, F. Essmann et al., “The centrosomal protein TACC3 controls paclitaxel sensitivity by modulating a premature senescence program,” Oncogene, vol. 29, no. 46, pp. 6184–6192, 2010.
- P. Duesberg, A. Fabarius, and R. Hehlmann, “Aneuploidy, the primary cause of the multilateral genomic instability of neoplastic and preneoplastic cells,” IUBMB Life, vol. 56, no. 2, pp. 65–81, 2004.
- N. J. Ganem, Z. Storchova, and D. Pellman, “Tetraploidy, aneuploidy and cancer,” Current Opinion in Genetics and Development, vol. 17, no. 2, pp. 157–162, 2007.
- H. Fujisawa, T. Nishikawa, B. H. Zhu et al., “Accelerated aging of dermal fibroblast-like cells from the senescence- accelerated mouse (SAM): acceleration of changes in DNA ploidy associated with in vitro cellular aging,” Journals of Gerontology. Series A, vol. 53, no. 1, pp. B11–B17, 1998.
- M. Wagner, B. Hampel, D. Bernhard, M. Hala, W. Zwerschke, and P. Jansen-Dürr, “Replicative senescence of human endothelial cells in vitro involves G1 arrest, polyploidization and senescence-associated apoptosis,” Experimental Gerontology, vol. 36, no. 8, pp. 1327–1347, 2001.
- M. R. Jones and K. Ravid, “Vascular smooth muscle polyploidization as a biomarker for aging and its impact on differential gene expression,” Journal of Biological Chemistry, vol. 279, no. 7, pp. 5306–5313, 2004.
- K. H. Walen, “Bipolar genome reductional division of human near-senescent, polyploid fibroblast cells,” Cancer Genetics and Cytogenetics, vol. 173, no. 1, pp. 43–50, 2007.