Research Article

PGC-1α Induction in Pulmonary Arterial Hypertension

Table 1

Clinical, molecular, and biochemical features of IPAH patients.

IDAge (years)SexPaO2 (mmHg)6 MWT (m)PAP (mmHg)CI (L/min/m2)PVR (dyn/sec/cm2)VRPGC-1α RECYTC RESOD RETAS (mM)GPX (nmol/min/mL)Treatment

HP145F67595481.312.4No2.872.454.120.2170.23e + b
HP275M62255701.811No0.340.420.240.0523.76a + s + i
HP334F85554352.86.2YES67.0038.507.450.28119.05n
HP458F70380482.212No6.075.472.290.1967.89b + t
HP538F83450383.246.1YES8.966.9526.770.1591.27n
HP663F68360402.18.5No3.222.594.640.2585.91i + b + s
HP764M60240532.37.7No0.340.480.140.0420.22b + s + t
HP866M57334501.88.6No1.411.010.130.1145.42s + i + b
HP960F58120491.118.9No0.340.080.130.0224.26s + i + b
HP1055F63320312.57.5YES7.768.343.470.2290.85b + s
HP1148F62534591.413.6No0.330.360.170.0619.21e + s + b
HP1272F60280652.212.5No0.220.210.500.0114.34i + b

PaO2: partial pressure of oxygen in arterial blood, 6MWT: 6-minute walk test, PAP: pulmonary arterial pressure, CI: cardiac index, PVR: pulmonary vascular resistance, VR: vasoreactivity, PGC-1α: peroxisome proliferator-activated receptor gamma coactivator 1-α, RE: relative mRNA expression, CYTC: cytochrome c, SOD: superoxide dismutase, TAS: total antioxidant status, GPX: glutathione peroxidase, e: epoprostenol, si: sildenafil, i: iloprost, b: bosentan, t: treprostinil, and n: nifedipine.