Recent Advances in the Treatment of Neurodegenerative Diseases Based on GSH Delivery Systems

Table 1

Kinetic data for chemical hydrolysis of codrugs 1-2, 5, and 9–14 at 37°C.

	pH 1.3^a		pH 7.4^a
Compd	𝑡1/2 (h)	𝐾obs (h^−1)	𝑡1/2 (h)	𝐾obs (h^−1)
1	20.14(±0.73)	0.034(±1.2×10^−3)	7.22(±0.31)	0.096(±4.1×10^−3)
2	28.12(±1.21)	0.025(±1.1×10^−3)	12.23(±0.49)	0.057(±2.3×10^−3)
5	20.67(±0.83)	0.094(±0.3×10^−3)	10.80(±0.40)	0.018(±0.8×10^−3)
9	301.0(±10.5)	0.002(±0.07×10^−3)	46.2(±0.90)	0.015(±0.3×10^−3)
10	290.6(±5.8)	0.002(±0.04×10^−3)	48.0(±1.70)	0.015(±0.45×10^−3)
11	296.3(±11.8)	0.002(±0.08×10^−3)	30.2(±1.40)	0.023(±1.04×10^−3)
12	292.1(±4.4)	0.002(±0.03×10^−3)	26.9(±0.70)	0.026(±0.65×10^−3)
13	292.8(±8.8)	0.002(±0.06×10^−3)	48.50(±0.70)	0.005(±0.25×10^−3)
14	293.4(±14.7)	0.002(±0.1×10^−3)	21.3(±0.60)	0.033(±0.99×10^−3)

^aValues are means of three experiments, and standard deviation is given in parentheses.