Table 1: Kinetic data for chemical hydrolysis of codrugs 1-2, 5, and 9–14 at 37°C.

pH 1.3apH 7.4a
Compd (h) (h−1) (h) (h−1)

1
2
5
9
10
11
12
13
14

aValues are means of three experiments, and standard deviation is given in parentheses.