Table 2: Rate constants for the hydrolysis of codrugs 1-2, 5, and 9–14 in 80% rat plasma and 80% human plasma at 37°C.

Rat plasmaaHuman plasmaa
Compd (min) (min−1) (min) (min−1)

1immediate hydrolysis
2
5
9
10
11
12
13
14

aValues are means of three experiments, standard deviation is given in parentheses.