Recent Advances in the Treatment of Neurodegenerative Diseases Based on GSH Delivery Systems

Table 2

Rate constants for the hydrolysis of codrugs 1-2, 5, and 9–14 in 80% rat plasma and 80% human plasma at 37°C.

	Rat plasma^a		Human plasma^a
Compd	𝑡1/2 (min)	𝐾obs (min^−1)	𝑡1/2 (min)	𝐾obs (min^−1)
1	immediate hydrolysis	—	3.2(±0.1)	0.217(±6×10^−3)
2	2.7(±0.1)	0.257(±8×10^−3)	15.1(±0.4)	0.046(±1×10^−3)
5	4.7(±0.1)	0.150(±0.01)	7.3(±0.3)	0.100(±0.01)
9	46.8(±1.4)	0.010(±0.20×10^−3)	69.6(±1.4)	0.015(±0.44×10^−3)
10	36.6(±1.6)	0.019(±0.85×10^−3)	65.4(±1.6)	0.011(±0.26×10^−3)
11	115.2(±11.0)	0.002(±0.07×10^−3)	315.0(±4.6)	0.006(±0.24×10^−3)
12	93.0(±10.2)	0.003(±0.17×10^−3)	263.4(±1.9)	0.007(±0.14×10^−3)
13	55.8(±10.5)	0.003(±0.11×10^−3)	203.4(±0.6)	0.030(±0.75𝑥10−3)
14	69.6(±3.5)	0.010(±0.50×10^−3)	90.0(±2.7)	0.008(±0.24×10^−3)

^aValues are means of three experiments, standard deviation is given in parentheses.