Research Article

Low-Dose Radiation Activates Akt and Nrf2 in the Kidney of Diabetic Mice: A Potential Mechanism to Prevent Diabetic Nephropathy

Figure 2

Effects of LDR on renal Akt function in diabetic mice. Renal tissues from mice exposed to sham, single 25 mGy, 75 mGy or 3 × 25 mGy of X-rays were collected at 1, 3, 6, 9, and 12 h after LDR to localize the phosphorylated Akt (p-Akt) at Ser473 with immunohistochemical staining ((a), the representative images of the staining were from the group of 75 mGy of LDR). The expression levels of total Akt and p-Akt were also examined by western blotting (b), followed by quantitative analysis (c). Data was presented as mean ± SD.   versus DM. Definition of the abbreviations is provided in Figure 1 legend.
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291087.fig.002b
(b)
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(c)