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Oxidative Medicine and Cellular Longevity
Volume 2012 (2012), Article ID 310534, 8 pages
http://dx.doi.org/10.1155/2012/310534
Research Article

Persistent Amplification of DNA Damage Signal Involved in Replicative Senescence of Normal Human Diploid Fibroblasts

1Department of Radiation Medical Sciences, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8523, Japan
2Laboratory of Radiation Biology, Department of Biological Science, Graduate School of Science, Osaka Prefecture University, Sakai, Osaka 599-8570, Japan
3Radiation Biology Center, Kyoto University, Kyoto 606-8501, Japan

Received 1 June 2012; Revised 26 July 2012; Accepted 13 August 2012

Academic Editor: William C. Burhans

Copyright © 2012 Masatoshi Suzuki et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [3 citations]

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  • Alice C. Holly, David Melzer, Luke C. Pilling, Alexander C. Fellows, Toshiko Tanaka, Luigi Ferrucci, and Lorna W. Harries, “Changes in splicing factor expression are associated with advancing age in man,” Mechanisms of Ageing and Development, 2013. View at Publisher · View at Google Scholar
  • Maria Moroni, William M. Bonner, Daisuke Maeda, and Mark H. Whitnall, “Evaluation of the Gamma-H2AX Assay for Radiation Biodosimetry in a Swine Mo del,” International Journal Of Molecular Sciences, vol. 14, no. 7, pp. 14119–14135, 2013. View at Publisher · View at Google Scholar
  • Hiroyasu Sakai, Hidetsugu Fujigaki, Sharlyn J Mazur, and Ettore Appella, “Wild-type p53-induced phosphatase 1 (Wip1) forestalls cellular premature senescence at physiological oxygen levels by regulating DNA damage response signaling during DNA replication,” Cell Cycle, vol. 13, no. 6, pp. 0–14, 2014. View at Publisher · View at Google Scholar