Pleiotropic Cellular Functions of PARP1 in Longevity and Aging: Genome Maintenance Meets Inflammation

Figure 3

Interaction map between PARP1 and Werner syndrome protein (WRN). The two proteins share many overlapping interaction pathways. There is a reciprocal interaction with DNA-PK (double-headed arrow) and p53, stimulation of base excision repair (BER, one-headed arrow), and inhibition of TRF2-DNA binding (blocked arrow). PARP1 also inhibits WRN functions if in an unmodified state (reproduced from [113]).