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Oxidative Medicine and Cellular Longevity
Volume 2012 (2012), Article ID 349710, 13 pages
http://dx.doi.org/10.1155/2012/349710
Review Article

Exercise in the Metabolic Syndrome

1Department of Anesthesiology, Pharmacology and Therapeutics, Faculty of Medicine, The University of British Columbia, Vancouver, BC, Canada V6T 1Z3
2Physiology Research Center, Kashan University of Medical Sciences and Health Services, Kashan 87155/111, Iran

Received 27 March 2012; Accepted 13 May 2012

Academic Editor: Steve R. McAnulty

Copyright © 2012 Saeid Golbidi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The metabolic syndrome is a clustering of obesity, diabetes, hyperlipidemia, and hypertension that is occurring in increasing frequency across the global population. Although there is some controversy about its diagnostic criteria, oxidative stress, which is defined as imbalance between the production and inactivation of reactive oxygen species, has a major pathophysiological role in all the components of this disease. Oxidative stress and consequent inflammation induce insulin resistance, which likely links the various components of this disease. We briefly review the role of oxidative stress as a major component of the metabolic syndrome and then discuss the impact of exercise on these pathophysiological pathways. Included in this paper is the effect of exercise in reducing fat-induced inflammation, blood pressure, and improving muscular metabolism.