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Oxidative Medicine and Cellular Longevity
Volume 2012 (2012), Article ID 356301, 4 pages
http://dx.doi.org/10.1155/2012/356301
Clinical Study

Decrease of Total Antioxidative Capacity in Developed Low Cardiac Output Syndrome

1Özel Yaşam Hastanesi Life Hospital, Antalya, Turkey
2Özel Çekirge Kalp ve Artimi Hastanesi, Bursa, Turkey

Received 23 June 2012; Accepted 14 October 2012

Academic Editor: Manikandan Panchatcharam

Copyright © 2012 Alper Sami Kunt and Mehmet Halit Andac. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. It has been known that cardiac surgery induces an oxidative stress. The persistent oxidative stress during reperfusion may lead to depressed myocardial function resulting in low cardiac output syndrome (LCOS) necessitating inotropic or intra-aortic balloon counterpulsation support. Total antioxidant capacity (TAC) is a measurement of oxidative stress in tissues. The purpose of this study was to examine the TAC differences during coronary artery bypass graft (CABG) operation in patients who have developed LCOS and who have not. Material and Methods. Seventy-nine patients were enrolled in the study. Central venous blood samples were obtained immediately before surgery, during operation, and at the end of surgery to assess TAC. Clinical data regarding patient demographics and operative outcomes were prospectively collected and entered into our clinical database. Results. LCOS developed in 8 patients (10.12%). The TAC has decreased sharply in the LCOS patients compared with those who did not develop LCOS during operation. In addition, the receiver operating characteristic (ROC) area was 0.879. Conclusion. TAC has decreased during operation in a significant proportion of patients undergoing isolated CABG, and this is more prominent and serious and might be an independent variable in patients who have developed LCOS. This may be related to intraoperative misadventure or inadequate myocardial antioxidative protection. Routine measurement of the TAC during operation may provide information for assessment of the LCOS development.