About this Journal Submit a Manuscript Table of Contents
Oxidative Medicine and Cellular Longevity
Volume 2012 (2012), Article ID 386286, 10 pages
http://dx.doi.org/10.1155/2012/386286
Research Article

Silica Nanoparticles Sensitize Human Multiple Myeloma Cells to Snake (Walterinnesia aegyptia) Venom-Induced Apoptosis and Growth Arrest

1Clinical Pathology Department, South Egypt Cancer Institute, Assiut University, Assiut 171515, Egypt
2Zoology Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia
3Princess Johara Alibrahim Center for Cancer Research, Prostate Cancer Research Chair, College of Medicine, King Saud University, P.O. Box 7805, Riyadh 11472, Saudi Arabia
4Zoology Department, Faculty of Science, Assiut University, Assiut 71516, Egypt

Received 26 September 2012; Revised 2 November 2012; Accepted 2 November 2012

Academic Editor: Zhao Zhong Chong

Copyright © 2012 Douaa Sayed et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. Gupta, T. Hideshima, and K. C. Anderson, “Novel biologically based therapeutic strategies in myeloma,” Reviews in Clinical and Experimental Hematology, vol. 6, no. 3, pp. 301–324, 2002. View at Publisher · View at Google Scholar · View at Scopus
  2. M. Zhao, J. Ma, H.-Y. Zhu, et al., “Apoptosis in human multiple myeloma cells through targeting the trinity of CK2, Cdc37 and Hsp90,” Molecular Cancer, vol. 10, article 104, 2011.
  3. F. S. Markland, K. Shieh, Q. Zhou et al., “A novel snake venom disintegrin that inhibits human ovarian cancer dissemination and angiogenesis in an orthotopic nude mouse model,” Haemostasis, vol. 31, no. 3–6, pp. 183–191, 2001. View at Scopus
  4. G. Badr, M. K. Al-Sadoon, A. M. El-Toni, and M. Daghestani, “Walterinnesia aegyptia venom combined with silica nanoparticles enhances the functioning of normal lymphocytes through PI3K/AKT, NFκB and ERK signaling,” Lipids in Health and Disease, vol. 11, article 27, 2012.
  5. D. J. Son, M. H. Park, S. J. Chae et al., “Inhibitory effect of snake venom toxin from Vipera lebetina turanica on hormone-refractory human prostate cancer cell growth: induction of apoptosis through inactivation of nuclear factor κB,” Molecular Cancer Therapeutics, vol. 6, no. 2, pp. 675–683, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. G. Barratt, “Colloidal drug carriers: achievements and perspectives,” Cellular and Molecular Life Sciences, vol. 60, no. 1, pp. 21–37, 2003. View at Publisher · View at Google Scholar · View at Scopus
  7. M. K. Al-Sadoon, M. A. Abdel-Maksoud, and D. M. Rabah, “Badr G. Induction of apoptosis and growth arrest in human breast carcinoma cells by a snake (Walterinnesia aegyptia) venom combined with silica nanoparticles: crosstalk between Bcl2 and caspase 3,” Cellular Physiology and Biochemistry, vol. 30, no. 3, pp. 653–665, 2012.
  8. M. H. Park, M. R. Jo, D. Won et al., “Snake venom toxin from Vipera lebetina turanica induces apoptosis in colon cancer cells via upregulation of ROS- and JNK-mediated death receptor expression,” BMC Cancer, vol. 12, no. 12, article 228, 2012.
  9. J. K. Song, M. R. Jo, M. H. Park, et al., “Cell growth inhibition and induction of apoptosis by snake venom toxin in ovarian cancer cell via inactivation of nuclear factor κB and signal transducer and activator of transcription 3,” Archives of Pharmacal Research, vol. 35, no. 5, pp. 867–876, 2012.
  10. E. M. Bruckheimer and N. Kyprianou, “Apoptosis in prostate carcinogenesis: a growth regulator and a therapeutic target,” Cell and Tissue Research, vol. 301, no. 1, pp. 153–162, 2000. View at Scopus
  11. T. Nishihori and M. Alsina, “Advances in the autologous and allogeneic transplantation strategies for multiple myeloma,” Cancer Control, vol. 18, pp. 258–267, 2011.
  12. Y. Ishii, H. H. Hsiao, G. Sashida et al., “Derivative (1;7)(q10;p10) in multiple myeloma. A sign of therapy-related hidden myelodysplastic syndrome,” Cancer Genetics and Cytogenetics, vol. 167, no. 2, pp. 131–137, 2006. View at Publisher · View at Google Scholar · View at Scopus
  13. G. Badr, E. A. Lefevre, and M. Mohany, “Thymoquinone inhibits the CXCL12-induced chemotaxis of multiple myeloma cells and increases their susceptibility to Fas-mediated apoptosis,” PLoS ONE, vol. 6, no. 9, Article ID e23741, 2011.
  14. L. P. Kolluru, S. A. Rizvi, M. D'Souza, and M. J. D'Souza, “Formulation development of albumin based theragnostic nanoparticles as a potential delivery system for tumor targeting,” Journal of Drug Targeting. In press.
  15. H. Hillaireau and P. Couvreur, “Nanocarriers' entry into the cell: relevance to drug delivery,” Cellular and Molecular Life Sciences, vol. 66, no. 17, pp. 2873–2896, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. J. Wang, M. Sui, and W. Fan, “Nanoparticles for tumor targeted therapies and their pharmacokinetics,” Current Drug Metabolism, vol. 11, no. 2, pp. 129–141, 2010. View at Publisher · View at Google Scholar · View at Scopus
  17. F. Haque, D. Shu, Y. Shu, et al., “Ultrastable synergistic tetravalent RNA nanoparticles for targeting to cancers,” Nano Today, vol. 7, pp. 245–257, 2012.
  18. H. Y. Nam, S. M. Kwon, H. Chung et al., “Cellular uptake mechanism and intracellular fate of hydrophobically modified glycol chitosan nanoparticles,” Journal of Controlled Release, vol. 135, no. 3, pp. 259–267, 2009. View at Publisher · View at Google Scholar · View at Scopus
  19. H. Koo, M. S. Huh, I. C. Sun, et al., “In vivo targeted delivery of nanoparticles for theranosis,” Accounts of Chemical Research, vol. 44, pp. 1018–1028, 2011.
  20. S. M. Lim, T. H. Kim, H. H. Jiang et al., “Improved biological half-life and anti-tumor activity of TNF-related apoptosis-inducing ligand (TRAIL) using PEG-exposed nanoparticles,” Biomaterials, vol. 32, no. 13, pp. 3538–3546, 2011. View at Publisher · View at Google Scholar · View at Scopus
  21. B. Koppolu, Z. Bhavsar, A. S. Wadajkar, et al., “Temperature-sensitive polymer-coated magnetic nanoparticles as a potential drug delivery system for targeted therapy of thyroid cancer,” Journal of Biomedical Nanotechnology, vol. 8, pp. 983–990, 2012.
  22. X. Zeng, Y. Zhang, and A. M. Nyström, “Endocytic uptake and intracellular trafficking of bis-MPA based hyperbranched copolymer micelles in breast cancer cells,” Biomacromolecules, vol. 13, no. 11, pp. 3814–3822, 2012.
  23. T. Lühmann, M. Rimann, A. G. Bittermann, and H. Hall, “Cellular uptake and intracellular pathways of PLL-g-PEG-DNA nanoparticles,” Bioconjugate Chemistry, vol. 19, no. 9, pp. 1907–1916, 2008. View at Publisher · View at Google Scholar · View at Scopus
  24. J. Ahmad, M. Ahamed, M. J. Akhtar et al., “Apoptosis induction by silica nanoparticles mediated through reactive oxygen species in human liver cell line HepG2,” Toxicology and Applied Pharmacology, vol. 259, no. 2, pp. 160–168, 2012.
  25. T. Kozako, N. Arima, M. Yoshimitsu, S. I. Honda, and S. Soeda, “Liposomes and nanotechnology in drug development: focus on oncotargets,” International Journal of Nanomedicine, vol. 7, pp. 4943–4951, 2012.
  26. T. Dos Santos, J. Varela, I. Lynch, A. Salvati, and K. A. Dawson, “Effects of transport inhibitors on the cellular uptake of carboxylated polystyrene nanoparticles in different cell lines,” PLoS ONE, vol. 6, Article ID e24438, 2011.