Metformin Rescues the Myocardium from Doxorubicin-Induced Energy Starvation and Mitochondrial Damage in Rats

Table 2

The protective effect of MET against DOX-induced cardiac myocyte injury.

Treatment group	CK-MB (U/L)	LDH (U/L)
Control	331±16	342±35
DOX	1125±94^∗	1299±122^∗
MET, 50 mg/kg	342±24^#	375±25^#
MET, 500 mg/kg	349±36^#	354±32^#
DOX + MET, 50 mg	903±69^∗	1030±67^∗
DOX + MET, 500 mg	439±47^#	417±36^#

All data represent mean values ± SEM (𝑛=10).
*indicates significant change from control, at 𝑃<0.05.
^#indicates significant change from DOX, at 𝑃<0.05.