Metformin Rescues the Myocardium from Doxorubicin-Induced Energy Starvation and Mitochondrial Damage in Rats

Table 3

MET rescues the myocardium from DOX-induced depletion of intramitochondrial CoA-SH.

Treatment groups	CoA-SH (nmol/mg protein)	Acetyl-CoA (nmol/mg protein)
Control	3.26±0.16	13.41±0.62
DOX	1.89±0.24^∗	22.31±0.89^∗
MET, 50 mg/kg	2.91±0.29^#	12.19±0.59^#
MET, 500 mg/kg	4.22±0.20^∗#	8.01±0.40^∗#
DOX + MET, 50 mg/kg	2.77±0.16	19.28±0.93^∗
DOX + MET, 500 mg/kg	3.06±0.18^#	15.44±0.78^#

All data represent mean values ± SEM (𝑛=10).
*indicates significant change from control, at 𝑃<0.05.
^#indicates significant change from DOX, at 𝑃<0.05.