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Oxidative Medicine and Cellular Longevity
Volume 2012 (2012), Article ID 489690, 6 pages
http://dx.doi.org/10.1155/2012/489690
Research Article

Cholesterol-Lowering Effect of Allicin on Hypercholesterolemic ICR Mice

1College of Biological and Environmental Engineering, Zhejiang Shuren University, Hangzhou 310015, China
2Institute of Bioengineering, Zhejiang Academy of Medical Science, Hangzhou 310013, China
3School of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou 310023, China
4Department of Biology, Shaoxing No.1 High School, Shengli West Road 1199, Yuecheng District, Shaoxing 312000, China
5Cardiovascular Department, Integrated Chinese and Western Medicine Hospital, Hangzhou Shangcheng District, Hangzhou 310008, China

Received 13 March 2012; Accepted 12 June 2012

Academic Editor: Michal Wozniak

Copyright © 2012 Yin Lu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Allicin was discussed as an active compound with regard to the beneficial effects of garlic in atherosclerosis. The aim of this study was to investigate the cholesterol-lowering properties of allicin. In order to examine its effects on hypercholesterolemia in male ICR mice, this compound with doses of 5, 10, or 20 mg/kg body weight was given orally daily for 12 weeks. Changes in body weight and daily food intake were measured regularly during the experimental period. Final contents of serum cholesterol, triglyceride, glucose, and hepatic cholesterol storage were determined. Following a 12-week experimental period, the body weights of allicin-fed mice were less than those of control mice on a high-cholesterol diet by % ( ) with 5 mg/kg allicin, % ( ) with 10 mg/kg allicin, and % ( ) with 20 mg/kg allicin, respectively. A decrease in daily food consumption was also noted in most of the treated animals. Meanwhile, allicin showed a favorable effect in reducing blood cholesterol, triglycerides, and glucose levels and caused a significant decrease in lowering the hepatic cholesterol storage. Accordingly, both in vivo and in vitro results demonstrated a potential value of allicin as a pronounced cholesterol-lowering candidate, providing protection against the onset of atherosclerosis.