- About this Journal ·
- Abstracting and Indexing ·
- Advance Access ·
- Aims and Scope ·
- Annual Issues ·
- Article Processing Charges ·
- Articles in Press ·
- Author Guidelines ·
- Bibliographic Information ·
- Citations to this Journal ·
- Contact Information ·
- Editorial Board ·
- Editorial Workflow ·
- Free eTOC Alerts ·
- Publication Ethics ·
- Reviewers Acknowledgment ·
- Submit a Manuscript ·
- Subscription Information ·
- Table of Contents
Oxidative Medicine and Cellular Longevity
Volume 2012 (2012), Article ID 489690, 6 pages
Cholesterol-Lowering Effect of Allicin on Hypercholesterolemic ICR Mice
1College of Biological and Environmental Engineering, Zhejiang Shuren University, Hangzhou 310015, China
2Institute of Bioengineering, Zhejiang Academy of Medical Science, Hangzhou 310013, China
3School of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou 310023, China
4Department of Biology, Shaoxing No.1 High School, Shengli West Road 1199, Yuecheng District, Shaoxing 312000, China
5Cardiovascular Department, Integrated Chinese and Western Medicine Hospital, Hangzhou Shangcheng District, Hangzhou 310008, China
Received 13 March 2012; Accepted 12 June 2012
Academic Editor: Michal Wozniak
Copyright © 2012 Yin Lu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- D. Steinberg, S. Parthasarathy, T. E. Carew, J. C. Khoo, and J. L. Witztum, “Beyond cholesterol: modifications of low-density lipoprotein that increase its atherogenicity,” The New England Journal of Medicine, vol. 320, no. 14, pp. 915–924, 1989.
- H. Esterbauer, J. Gebicki, H. Puhl, and G. Jurgens, “The role of lipid peroxidation and antioxidants in oxidative modification of LDL,” Free Radical Biology and Medicine, vol. 13, no. 4, pp. 341–390, 1992.
- K. S. Bramlett, K. A. Houck, K. M. Borchert et al., “A natural product ligand of the oxysterol receptor, liver X receptor,” Journal of Pharmacology and Experimental Therapeutics, vol. 307, no. 1, pp. 291–296, 2003.
- L. K. Han, Y. N. Zheng, B. J. Xu, H. Okuda, and Y. Kimura, “Saponins from Platycodi radix ameliorate high fat diet-induced obesity in mice,” Journal of Nutrition, vol. 132, no. 8, pp. 2241–2245, 2002.
- K. C. Agarwal, “Therapeutic actions of garlic constituents,” Medicinal Research Reviews, vol. 16, pp. 111–124, 1996.
- S. Phelps and W. S. Harris, “Garlic supplementation and lipoprotein oxidation susceptibility,” Lipids, vol. 28, no. 5, pp. 475–477, 1993.
- C. Legnani, M. Frascaro, G. Guazzaloca, S. Ludovici, G. Cesarano, and S. Coccheri, “Effects of a dried garlic preparation on fibrinolysis and platelet aggregation in healthy subjects,” Arzneimittel-Forschung/Drug Research, vol. 43, no. 2, pp. 119–122, 1993.
- E. S. Lee, M. Steiner, and R. Lin, “Thioallyl compounds: potent inhibitors of cell proliferation,” Biochimica et Biophysica Acta, vol. 1221, no. 1, pp. 73–77, 1994.
- A. N. Orekhov, V. V. Tertov, I. A. Sobenin, and E. M. Pivovarova, “Direct anti-atherosclerosis-related effects of garlic,” Annals of Medicine, vol. 27, no. 1, pp. 63–65, 1995.
- K. K. Al-Qattan, M. A. Alnaqeeb, and M. Ali, “The antihypertensive effect of garlic (Allium sativum) in the rat two- kidney-one-clip Goldblatt model,” Journal of Ethnopharmacology, vol. 66, no. 2, pp. 217–222, 1999.
- S. Bolton, G. Null, and W. M. Troetel, “The medical uses of garlic—fact and fiction,” American Pharmacy, vol. NS22, no. 8, pp. 40–43, 1982.
- H. D. Reuter, H. P. Koch, and L. D. Lawson, “Therapeutic effects and applications of garlic and its preparations,” in The Science and Therapeutic Application of Allium Sativum and Related Species, H. P. Koch and L. Lawson LDGarlic, Eds., Williams and Wilkins, Baltimore, Md, USA, 1996.
- D. Abramovitz, S. Gavri, D. Harats et al., “Allicin-induced decrease in formation of fatty streaks (atherosclerosis) in mice fed a cholesterol-rich diet,” Coronary Artery Disease, vol. 10, no. 7, pp. 515–519, 1999.
- S. K. Banerjee and S. K. Maulik, “Effect of garlic on cardiovascular disorders: a review,” Nutrition Journal, vol. 1, article 1, pp. 1–14, 2002.
- L. D. Brace, “Cardiovascular benefits of garlic (Allium sativum L.),” Journal of Cardiovascular Nursing, vol. 16, no. 4, pp. 33–49, 2002.
- M. J. Kwon, Y. S. Song, M. S. Choi, S. J. Park, K. S. Jeong, and Y. O. Song, “Cholesteryl ester transfer protein activity and atherogenic parameters in rabbits supplemented with cholesterol and garlic powder,” Life Sciences, vol. 72, no. 26, pp. 2953–2964, 2003.
- S. M. S. Espirito Santo, B. J. M. van Vlijmen, R. Buytenhek et al., “Well-characterized garlic-derived materials are not hypolipidemic in APOE*3-Leiden transgenic mice,” Journal of Nutrition, vol. 134, no. 6, pp. 1500–1503, 2004.
- G. F. Watts, B. Lewis, J. N. H. Brunt et al., “Effects on coronary artery disease of lipid-lowering diet, or diet plus cholestyramine, in the St Thomas' Atherosclerosis Regression Study (STARS),” The Lancet, vol. 339, no. 8793, pp. 563–569, 1992.
- B. Paigen, A. Morrow, and C. Brandon, “Variation in susceptibility to atherosclerosis among inbred strains of mice,” Atherosclerosis, vol. 57, no. 1, pp. 65–73, 1985.
- S. Eilat, Y. Oestraicher, A. Rabinkov et al., “Alteration of lipid profile in hyperlipidemic rabbits by allicin, an active constituent of garlic,” Coronary Artery Disease, vol. 6, no. 12, pp. 985–990, 1995.
- A. Gonen, D. Harats, A. Rabinkov et al., “The antiatherogenic effect of allicin: possible mode of action,” Pathobiology, vol. 72, no. 6, pp. 325–334, 2005.
- A. Coppi, M. Cabinian, D. Mirelman, and P. Sinnis, “Antimalarial activity of allicin, a biologically active compound from garlic cloves,” Antimicrobial Agents and Chemotherapy, vol. 50, no. 5, pp. 1731–1737, 2006.
- J. George, A. Afek, B. Gilburd et al., “Hyperimmunization of apo-E-deficient mice with homologous malondialdehyde low-density lipoprotein suppresses early atherogenesis,” Atherosclerosis, vol. 138, no. 1, pp. 147–152, 1998.