Review Article

The Role of Dietary Polyphenols on Adult Hippocampal Neurogenesis: Molecular Mechanisms and Behavioural Effects on Depression and Anxiety

Figure 3

Effects of curcumin on stress. Administration of curcumin in rodent models of stress has been found to reduce stress-related behaviours, with decreased levels of the stress hormone corticosterone and increased levels of glucocorticoid receptor (GR) mRNA expression, brain-derived neurotrophic factor (BDNF), and phosphorilated cyclic AMP-response element DNA-binding protein (pCREB). Additionally, the decrease in AHN observed after exposure to stress has been found to be reversed following administration of curcumin.
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