Table 1: Overview of the effect sod knockdown/out or overexpression of C. elegans superoxide dismutases on ROS levels, oxidative damage, and lifespan under stressed and unstressed condition (paraquat or hyperoxia). OE: overexpression; ND: not determined; PQ: paraquat; J: juglone; DR: dietary restriction.

sod geneROS levelsOxidative damageEffect on lifespanEffect on stress survivalEffect on lifespan long-lived worms

Knockdown/out

sod-2Increased [57] or no effect [27]Increased [30, 40]No effect [2931, 39] or increased [27, 40, 57]Decreased (PQ) [2931, 40] (J) [40] or no effect (hyperoxia) [29]No effect (daf-2) [29, 30, 40] (DR) [39] or decreased (daf-2) [31] or increased (clk-1) [30, 40]
MnSODsod-3Increased [57]NDNo effect [29, 31, 39, 40] or increased [57]Decreased (pathogenic bacteria) [58] (PQ-J) [40] or no effect (PQ-hyperoxia) [29, 31] or increased [39]No effect (daf-2) [29] (DR) [39, 40] or increased (daf-2) [31] or decreased (isp-1) [40]
sod-2;
sod-3
Increased [59] or decreased [60]No effect [29, 60]No effect [29, 31] or increased [40]Decreased (PQ-hyperoxia) [29, 31, 40] (J) [40]Increased (daf-2) [31]

sod-1Increased [61]Increased [30] or no effect [29]Decreased [29, 39, 61] or no effect [30, 39, 40]Decreased (PQ) [29, 30, 39, 40, 61] (J) [40] (hyperoxia) [29]Decreased (daf-2) [29] or no effect (DR) [39] or increased (daf-2) [30]
sod-4NDNDNo effect [29, 31, 39, 40]No effect [29] or increased [39]Increased (daf-2) [29] or no effect (DR) [39]
CuZnSODsod-5NDNDNo effect [29, 39, 40]No effect [29, 39]No effect (daf-2) [29] (DR) [39]
sod-1;
sod-4;NDNDDecreased [29]NDND
sod-5

SODsod-12345NDNo effect [62]No effect [62]Decreased [62]ND

OE

MnSODsod-2NDNo effect [63]Increased [63]NDND
CuZnSODsod-1Increased [63]Increased [63]Increased [29, 63]Decreased (PQ) [29]ND