ROS in Aging Caenorhabditis elegans: Damage or Signaling?

Table 1

Overview of the effect sod knockdown/out or overexpression of C. elegans superoxide dismutases on ROS levels, oxidative damage, and lifespan under stressed and unstressed condition (paraquat or hyperoxia). OE: overexpression; ND: not determined; PQ: paraquat; J: juglone; DR: dietary restriction.

	sod gene	ROS levels	Oxidative damage	Effect on lifespan	Effect on stress survival	Effect on lifespan long-lived worms
			Knockdown/out
	sod-2	Increased [57] or no effect [27]	Increased [30, 40]	No effect [29–31, 39] or increased [27, 40, 57]	Decreased (PQ) [29–31, 40] (J) [40] or no effect (hyperoxia) [29]	No effect (daf-2) [29, 30, 40] (DR) [39] or decreased (daf-2) [31] or increased (clk-1) [30, 40]
MnSOD	sod-3	Increased [57]	ND	No effect [29, 31, 39, 40] or increased [57]	Decreased (pathogenic bacteria) [58] (PQ-J) [40] or no effect (PQ-hyperoxia) [29, 31] or increased [39]	No effect (daf-2) [29] (DR) [39, 40] or increased (daf-2) [31] or decreased (isp-1) [40]
	sod-2; sod-3	Increased [59] or decreased [60]	No effect [29, 60]	No effect [29, 31] or increased [40]	Decreased (PQ-hyperoxia) [29, 31, 40] (J) [40]	Increased (daf-2) [31]
	sod-1	Increased [61]	Increased [30] or no effect [29]	Decreased [29, 39, 61] or no effect [30, 39, 40]	Decreased (PQ) [29, 30, 39, 40, 61] (J) [40] (hyperoxia) [29]	Decreased (daf-2) [29] or no effect (DR) [39] or increased (daf-2) [30]
	sod-4	ND	ND	No effect [29, 31, 39, 40]	No effect [29] or increased [39]	Increased (daf-2) [29] or no effect (DR) [39]
CuZnSOD	sod-5	ND	ND	No effect [29, 39, 40]	No effect [29, 39]	No effect (daf-2) [29] (DR) [39]
	sod-1;
	sod-4;	ND	ND	Decreased [29]	ND	ND
	sod-5
SOD	sod-12345	ND	No effect [62]	No effect [62]	Decreased [62]	ND
			OE
MnSOD	sod-2	ND	No effect [63]	Increased [63]	ND	ND
CuZnSOD	sod-1	Increased [63]	Increased [63]	Increased [29, 63]	Decreased (PQ) [29]	ND