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| Animal model | Antidepressant drugs tested | Main findings | Reference |
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| Male albino mice | Acute treatment | Bupropion (10–40 mg/kg), i.p., once, 30 min before brain sample acquisition | Modulated the L-arginine-NO-cyclic cGMP signalling pathway in rat brain | Dhir and Kulkarni, 2007 [13] |
| Female Swiss mice | Acute treatment | Escitalopram (3 mg/kg), p.o., once, 30 min before behavioural tests | Antidepressant-like effect was mediated by an inhibition of either the NMDA receptor activation or NO-cGMP synthesis | Zomkowski et al., 2010 [14] |
| Male C57Bl/6J mice | Acute treatment | Imipramine (15 mg/kg), venlafaxine (6 mg/kg), both drugs, i.p., once only | Decreased brain NO2 + NO3 levels in control mice | Krass et al., 2011 [15] |
| Male Wistar rats | Acute treatment | Amitriptyline (10 mg/kg), i.p., once only, 3 h before analyses | Drug did not alter NO2 + NO3 serum levels in control rats | Vismari et al., 2012 [16] |
| Male Wistar rats | Acute and chronic treatment | Fluoxetine (20 mg/kg once or 10 mg/kg/day), i.p., once only or once a day for 12 days | Showed stimulation of mitochondrial respiration in state 4 in acute or prolonged treatments, indicating uncoupling of oxidative phosphorylation in rat liver mitochondria | Souza et al., 1994 [7] |
| Male Wistar rats | Acute and chronic treatment | Imipramine (10, 20 and 30 mg/kg), i.p., once only or once a day for 14 days | Decreased MDA and carbonyl content and increased SOD and CAT activity in prefrontal cortex and hippocampus | Réus et al., 2010 [17] |
| Male Wistar rats | Acute and chronic treatment | Imipramine (10, 20 and 30 mg/kg), i.p., once only or once a day for 14 days | Increased brain creatine kinase and mitochondrial respiratory chain activities | Réus, et al., 2012 [18] |
| Male Wistar rats | Acute and chronic treatment | Imipramine (10, 20 and 30 mg/kg), i.p., once only or once a day for 14 days | Altered respiratory chain complexes and CK activities; these alterations were different with relation to protocols (acute or chronic), complex, dose, and brain area | Réus, et al., 2012 [53] |
| Female Swiss mice | Acute and chronic treatment | Fluoxetine (10 mg/kg), p.o., once only or once a day for 28 days | Acute treatment reduced GPx activity in hippocampus; chronic treatment increases GSH in both hippocampus and prefrontal cortex | Lobato et al., 2010 [19] |
| Female Wistar rats | Chronic treatment | Imipramine (10 mg/kg) twice daily, i.p., 1 or 2 weeks | Promoted stimulation of the states 3 and 4 respiration rates (1 and 2 week treatments) on rat brain mitochondria | Katyare and Rajan, 1995 [20] |
| Male Sprague-Dawley rats | Chronic treatment | Amitriptyline (5, 10 mg/kg/day), venlafaxine (5, 10 mg/kg/day), both drugs. i.p., for 3 weeks | Both drugs increased SOD immunostaining in the hippocampal neurons | Xu et al., 2003 [21] |
| Male Wistar Han rats | Chronic treatment | Fluoxetine, 8 and 24 mg/kg/day, p.o., for 4 weeks | Increased levels of carbonyl groups, TBARS, and the uric acid content in the liver, effects more pronounced at high dose | Inkielewicz-Stêpniak, 2011 [22] |
| Male Swiss albino mice | Acute treatment, with or without previous restraint stress protocol | Fluoxetine, 5 mg/kg/day, i.p., 30 min before restraint stress protocol | Partially reversed the adverse effects of stress (restraint stress significantly increases the generation of ROS in the peripheral defence cells) restoring SOD, CAT, and GSH levels | Novio et al., 2011 [23] |
| Swiss Albino rats | Chronic treatment, with or without previous restraint stress protocol | Fluoxetine (20 mg/kg/day), imipramine (10 mg/kg/day), venlafaxine (10 mg/kg/day), all drugs, p.o., for 3 weeks | All drugs restored SOD, CAT, GST, and GR activity, increased GSH and decreased MDA and carbonyl in brain samples of stressed animals | Zafir et al., 2009 [24] |
| Male Wistar rats | Chronic treatment, with or without previous chronic social isolation stress | Fluoxetine, 5 mg/kg/day, i.p., for 3 weeks | Decreased SOD and increased GPx activity in both groups, increased TAC in stressed animals, also induced several hallmarks of apoptosis in the liver of stressed animals | Djordjevic et al., 2011 [25] |
| Male Swiss-Webster mice | Chronic treatment, stress induced by FST and TST | Venlafaxine (5, 10, and 20 mg/kg/day), i.p. for 3 weeks | Decreased MDA and NO and increased hippocampal GSH and TAC levels and GST activity in the stressed animals, also, reduced both serum and hippocampal 8-OHdG levels | Abdel-Wahab and Salama, 2011 [26] |
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