Kluyveromyces lactis: A Suitable Yeast Model to Study Cellular Defense Mechanisms against Hypoxia-Induced Oxidative Stress
Table 2
Putative main actors of mitophagy and its signaling pathways in K. lactis and S. cerevisiae. Degree of identity (%) between homologs is indicated in Figure 2.
Protein
ORF K. lactis
ORF S. cerevisiae
Function
Atg1
KLLA0C17160g
YGL180W
Autophagy-dedicated protein serine/threonine kinase
Atg11
KLLA0B12133g
YPR049C
Cytoplasm-to-vacuole targeting (Cvt) pathway and peroxisomal degradation (pexophagy)
Atg32
KLLA0A00660g
YIL146C
Mitochondrial receptor specific to mitophagy
Atg33
KLLA0A02695g
YLR356W
Detects or presents aged mitochondria for degradation at the stationary phase
Atg8
KLLA0E20593g
YBL078C
Component of autophagosomes and Cvt vesicles
Aup1
KLLA0F06985g
YCR079W
Mitochondrial protein phosphatase
Bck1
KLLA0F14190g
YJL095W
MAP kinase kinase kinase acting in the protein kinase C signaling pathway
Dnm1
KLLA0F12892g
YLL001W
Dynamin-related GTPase
Fmc1
KLLA0F04081g
YIL098C
Assembly at high temperature of mitochondrial ATP synthase
Hog1
KLLA0F20053g
YLR113W
MAP kinase involved in osmoregulation
Mdm38
KLLA0B11748g
YOL027C
Mitochondrial distribution and morphology
Mkk1
KLLA0D07304g
YOR231W
MAP kinase kinase acting in the protein kinase C signaling pathway
Mkk2
KLLA0D07304g
YPL140C
MAP kinase kinase acting in the protein kinase C signaling pathway
Pbs2
KLLA0E15313g
YJL128C
MAP kinase kinase in the osmosensing signal-transduction pathway
Pkc1
KLLA0E06447g
YBL105C
Protein kinase C
Rtg3
KLLA0E06513g
YBL103C
Transcription factor to activate the retrograde (RTG) and TOR pathways
Slt2
KLLA0B11902g
YHR030C
MPK1 MAP kinase
Uth1
KLLA0E14939g
YKR042W
Regulator outer membrane protein
Whi2
KLLA0F15972g
YOR043W
Full activation of the general stress response
Wsc1
KLLA0D14377g
YOR008C
Sensor transducer of the stress-activated PKC1-MPK1 kinase pathway
Yme1
KLLA0E06711g
YPR024W
Protease catalytic subunit for degradation of unfolded or misfolded mitochondrial gene products
