Oxidative Stress and Immunosenescence: Therapeutic Effects of Melatonin

Table 2

Activation of different apoptotic events in thapsigargin-treated leukocytes from young and elderly individuals.

	Neutrophils		Lymphocytes
	Young	Aged	Young	Aged
MMD	+	+++	+	+++
Caspase-9 activity	+	+++	+	+++
Caspase-3 activity	+	++	+	++
PS exposure	+	++	+	++
DNA fragmentation	+	++	+	++

The degree of apoptosis was classified on a scale of + (indicating lowest apoptosis) to +++ (indicating highest apoptosis). MMD: mitochondrial membrane depolarization; PS: phosphatidylserine. Data were taken from Espino et al. 2011 [50].