Table 2: Activation of different apoptotic events in thapsigargin-treated leukocytes from young and elderly individuals.

NeutrophilsLymphocytes
YoungAgedYoungAged

MMD++++++++
Caspase-9 activity++++++++
Caspase-3 activity++++++
PS exposure++++++
DNA fragmentation++++++

The degree of apoptosis was classified on a scale of + (indicating lowest apoptosis) to +++ (indicating highest apoptosis). MMD: mitochondrial membrane depolarization; PS: phosphatidylserine. Data were taken from Espino et al. 2011 [50].