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Oxidative Medicine and Cellular Longevity
Volume 2012 (2012), Article ID 718491, 10 pages
Review Article

Nutraceutical Interventions for Promoting Healthy Aging in Invertebrate Models

1Department of Biological Sciences, Clemson University, 132 Long Hall, Clemson, SC 29634, USA
2Institute for Engaged Aging, Clemson University, 535A Edwards Hall, Clemson, SC 29634, USA
3Laboratory of Experimental Gerontology, National Institute on Aging, 251 Bayview Boulevard, Baltimore, MD 21224, USA

Received 22 June 2012; Revised 8 August 2012; Accepted 10 August 2012

Academic Editor: Heinz D. Osiewacz

Copyright © 2012 Yuqing Dong et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Aging is a complex and inevitable biological process that is associated with numerous chronically debilitating health effects. Development of effective interventions for promoting healthy aging is an active but challenging area of research. Mechanistic studies in various model organisms, noticeably two invertebrates, Caenorhabditis elegans and Drosophila melanogaster, have identified many genes and pathways as well as dietary interventions that modulate lifespan and healthspan. These studies have shed light on some of the mechanisms involved in aging processes and provide valuable guidance for developing efficacious aging interventions. Nutraceuticals made from various plants contain a significant amount of phytochemicals with diverse biological activities. Phytochemicals can modulate many signaling pathways that exert numerous health benefits, such as reducing cancer incidence and inflammation, and promoting healthy aging. In this paper, we outline the current progress in aging intervention studies using nutraceuticals from an evolutionary perspective in invertebrate models.