Schizandrin, an Antioxidant Lignan from Schisandra chinensis, Ameliorates Aβ_1–42-Induced Memory Impairment in Mice

Figure 2

Effects of SCH against Aβ _1–42-induced memory impairment in Y-maze test. Spontaneous alternation behavior (a) and total number of arm entries (b) were measured during an 8-min session. Sham-operated and control groups: mice were given distilled water orally (20 mL/kg). Positive control: mice were given DPZ 0.65 mg/kg, i.g. SCH-4, SCH-12, and SCH-36: mice were given 4, 12, and 36 mg/kg of SCH, i.g., respectively. Data in the bar graphs were represented as mean ± S.E.M. and analyzed by one-way ANOVA followed by LSD test for multiple comparisons (𝑛=8-10). ^###𝑃<0.001 compared with the sham-operated group; ^∗𝑃<0.05, ^∗∗𝑃<0.01 compared with the control group.

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