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Oxidative Medicine and Cellular Longevity
Volume 2012 (2012), Article ID 728430, 9 pages
http://dx.doi.org/10.1155/2012/728430
Review Article

DNA Mismatch Repair System: Repercussions in Cellular Homeostasis and Relationship with Aging

Universidad Autónoma Metropolitana Unidad Iztapalapa, 186 Avenida San Rafael Atlixco, 09340 Mexico City, DF, Mexico

Received 31 May 2012; Revised 24 September 2012; Accepted 8 October 2012

Academic Editor: William C. Burhans

Copyright © 2012 Juan Cristóbal Conde-Pérezprina et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The mechanisms that concern DNA repair have been studied in the last years due to their consequences in cellular homeostasis. The diverse and damaging stimuli that affect DNA integrity, such as changes in the genetic sequence and modifications in gene expression, can disrupt the steady state of the cell and have serious repercussions to pathways that regulate apoptosis, senescence, and cancer. These altered pathways not only modify cellular and organism longevity, but quality of life (“health-span”). The DNA mismatch repair system (MMR) is highly conserved between species; its role is paramount in the preservation of DNA integrity, placing it as a necessary focal point in the study of pathways that prolong lifespan, aging, and disease. Here, we review different insights concerning the malfunction or absence of the DNA-MMR and its impact on cellular homeostasis. In particular, we will focus on DNA-MMR mechanisms regulated by known repair proteins MSH2, MSH6, PMS2, and MHL1, among others.