Review Article

Is Physical Activity Able to Modify Oxidative Damage in Cardiovascular Aging?

Figure 1

Mechanism of exercise training through SIRT1 activity on antioxidant enzymes and factors involved in cell cycle. Exercise training induces increased SIRT1 activity that is responsible both of raised activation of antioxidants system (by MnSOD and Catalase) and cell cycle arrest to promote DNA repair. These phenomena could induce extended lifespan.
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