- About this Journal ·
- Abstracting and Indexing ·
- Aims and Scope ·
- Annual Issues ·
- Article Processing Charges ·
- Articles in Press ·
- Author Guidelines ·
- Bibliographic Information ·
- Citations to this Journal ·
- Contact Information ·
- Editorial Board ·
- Editorial Workflow ·
- Free eTOC Alerts ·
- Publication Ethics ·
- Reviewers Acknowledgment ·
- Submit a Manuscript ·
- Subscription Information ·
- Table of Contents
Oxidative Medicine and Cellular Longevity
Volume 2012 (2012), Article ID 728547, 6 pages
Is Physical Activity Able to Modify Oxidative Damage in Cardiovascular Aging?
1Department of Medicine and Health Sciences, University of Molise, Via Giovanni Paolo II, Località Tappino, 86100 Campobasso, Italy
2Department of Medicine and Sugery, University of Salerno, Via Salvador Allende, 84081 Baronissi (SA), Italy
3Istituto Scientifico di Campoli/Telese, Fondazione Salvatore Maugeri, IRCCS, Via Bagni Vecchi 1, 82037 Telese Terme (BN), Italy
Received 22 June 2012; Accepted 13 August 2012
Academic Editor: William C. Burhans
Copyright © 2012 Graziamaria Corbi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- G. Corbi, V. Conti, G. Scapagnini, A. Filippelli, and N. Ferrara, “Role of sirtuins, calorie restriction and physical activity in aging,” Frontiers in Bioscience (Elite Edition), vol. 4, pp. 768–778, 2012.
- S. Vasto, G. Scapagnini, M. Bulati et al., “Biomarkes of aging,” Frontiers in Bioscience (Scholar Edition), vol. 2, pp. 392–402, 2010.
- M. Galderisi, V. S. Lomoriello, A. Santoro, et al., “Differences of myocardial systolic deformation and correlates of diastolic function in competitive rowers and young hypertensives: a speckle-tracking echocardiography study,” Journal of the American Society of Echocardiography, vol. 23, no. 11, pp. 1190–1198, 2010.
- C. H. Davies, N. Ferrara, and S. E. Harding, “β-Adrenoceptor function changes with age of subject in myocytes from non-failing human ventricle,” Cardiovascular Research, vol. 31, no. 1, pp. 152–156, 1996.
- P. Abete, C. Napoli, G. Santoro et al., “Age-related decrease in cardiac tolerance to oxidative stress,” Journal of Molecular and Cellular Cardiology, vol. 31, no. 1, pp. 227–236, 1999.
- S. Besse, C. Delcayre, B. Chevalier et al., “Is the senescent heart overloaded and already failing?” Cardiovascular Drugs and Therapy, vol. 8, no. 4, pp. 581–587, 1994.
- G. Vitale, M. Galderisi, A. Colao, et al., “Circulating IGF-I levels are associated with increased biventricular contractility in top-level rowers,” Clinical Endocrinology (Oxford), vol. 69, no. 2, pp. 231–236, 2008.
- N. Ferrara, P. Abete, G. Corbi et al., “Insulin-induced changes in β-adrenergic response: an experimental study in the isolated rat papillary muscle,” American Journal of Hypertension, vol. 18, no. 3, pp. 348–353, 2005.
- L. Amato, G. Paolisso, F. Cacciatore, et al., “Congestive heart failure predicts the development of non-insulin-dependent diabetes mellitus in the elderly. The Osservatorio Geriatrico Regione Campania Group,” Diabetes and Metabolism, vol. 23, no. 3, pp. 213–218, 1997.
- M. Zheng, W. Zhu, Q. Han, and R. P. Xiao, “Emerging concepts and therapeutic implications of β-adrenergic receptor subtype signaling,” Pharmacology and Therapeutics, vol. 108, no. 3, pp. 257–268, 2005.
- N. Ferrara, K. Davia, P. Abete, F. Rengo, and S. E. Harding, “Alterations in β-adrenoceptor mechanisms in the aging heart. Relationship with heart failure,” Aging—Clinical and Experimental Research, vol. 9, no. 6, pp. 391–403, 1997.
- G. Rengo, C. Zincarelli, G. D. Femminella et al., “Myocardial β2-adrenoceptor gene delivery promotes coordinated cardiac adaptive remodelling and angiogenesis in heart failure,” British Journal of Pharmacology, vol. 166, no. 8, pp. 2348–2361, 2012.
- G. Rengo, A. Lymperopoulos, C. Zincarelli et al., “Blockade of β-adrenoceptors restores the GRK2-mediated adrenal α2-adrenoceptor-catecholamine production axis in heart failure,” British Journal of Pharmacology, vol. 166, no. 8, pp. 2430–2440, 2012.
- G. Corbi, D. Acanfora, G. L. Iannuzzi et al., “Hypermagnesemia predicts mortality in elderly with congestive heart disease: relationship with laxative and antacid use,” Rejuvenation Research, vol. 11, no. 1, pp. 129–138, 2008.
- K. L. Koss and R. D. Grubbs, “Elevated extracellular Mg2+ increases Mg2+ buffering through a Ca-dependent mechanism in cardiomyocytes,” American Journal of Physiology, vol. 267, no. 2, pp. C633–C641, 1994.
- S. Kawano, “Dual mechanisms of Mg2+ block of ryanodine receptor Ca2+ release channel from cardiac sarcoplasmic reticulum,” Receptors and Channels, vol. 5, no. 6, pp. 405–416, 1998.
- G. Longobardi, P. Abete, N. Ferrara et al., “‘Warm-up’ phenomenon in adult and elderly patients with coronary artery disease: further evidence of the loss of “ischemic preconditioning” in the aging heart,” Journals of Gerontology—Series A, vol. 55, no. 3, pp. M124–M129, 2000.
- P. Abete, A. Cioppa, C. Calabrese et al., “Ischemic threshold and myocardial stunning in the aging heart,” Experimental Gerontology, vol. 34, no. 7, pp. 875–884, 1999.
- C. P. Campobasso, A. S. Dell'Erba, A. Addante, F. Zotti, A. Marzullo, and M. F. Colonna, “Sudden cardiac death and myocardial ischemia indicators: a comparative study of four immunohistochemical markers,” American Journal of Forensic Medicine and Pathology, vol. 29, no. 2, pp. 154–161, 2008.
- N. Ferrara, P. Abete, G. Ambrosio et al., “Protective role of chronic ubiquinone administration on acute cardiac oxidative stress,” Journal of Pharmacology and Experimental Therapeutics, vol. 274, no. 2, pp. 858–865, 1995.
- B. Rinaldi, G. Corbi, S. Boccuti et al., “Exercise training affects age-induced changes in SOD and heat shock protein expression in rat heart,” Experimental Gerontology, vol. 41, no. 8, pp. 764–770, 2006.
- A. Navarro-Arévalo, C. Cañavate, and M. J. Sánchez-del-Pino, “Myocardial and skeletal muscle aging and changes in oxidative stress in relationship to rigorous exercise training,” Mechanisms of Ageing and Development, vol. 108, no. 3, pp. 207–217, 1999.
- P. K. Singal, A. Petkau, J. M. Gerrard, S. Hrushovetz, and J. Foerster, “Free radicals in health and disease,” Molecular and Cellular Biochemistry, vol. 84, no. 2, pp. 121–122, 1988.
- F. Gündüz, U. K. Sentürk, O. Kuru, B. Aktekin, and M. R. Aktekin, “The effect of one year's swimming exercise on oxidant stress and antioxidant capacity in aged rats,” Physiological Research, vol. 53, no. 2, pp. 171–176, 2004.
- J. L. Martin, R. Mestril, R. Hilal-Dandan, L. L. Brunton, and W. H. Dillmann, “Small heat shock proteins and protection against ischemic injury in cardiac myocytes,” Circulation, vol. 96, no. 12, pp. 4343–4348, 1997.
- L. H. E. H. Snoeckx, R. N. Cornelussen, F. A. Van Nieuwenhoven, R. S. Reneman, and G. J. Van Der Vusse, “Heat shock proteins and cardiovascular pathophysiology,” Physiological Reviews, vol. 81, no. 4, pp. 1461–1497, 2001.
- P. Anversa, B. Hiler, R. Ricci, G. Guideri, and G. Olivetti, “Myocyte cell loss and myocyte hypertrophy in the aging rat heart,” Journal of the American College of Cardiology, vol. 8, no. 6, pp. 1441–1448, 1986.
- S. Besse, V. Robert, P. Assayag, C. Delcayre, and B. Swynghedauw, “Nonsynchronous changes in myocardial collagen mRNA and protein during aging: effect of DOCA-salt hypertension,” American Journal of Physiology, vol. 267, no. 6, pp. H2237–H2244, 1994.
- M. Klima, T. R. Burns, and A. Chopra, “Mycardial fibrosis in the elderly,” Archives of Pathology and Laboratory Medicine, vol. 114, no. 9, pp. 938–942, 1990.
- O. Grubisha, B. C. Smith, and J. M. Denu, “Small molecule regulation of Sir2 protein deacetylases,” FEBS Journal, vol. 272, no. 18, pp. 4607–4616, 2005.
- A. Brunet, L. B. Sweeney, J. F. Sturgill et al., “Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase,” Science, vol. 303, no. 5666, pp. 2011–2015, 2004.
- M. Porcu and A. Chiarugi, “The emerging therapeutic potential of sirtuin-interacting drugs: from cell death to lifespan extension,” Trends in Pharmacological Sciences, vol. 26, no. 2, pp. 94–103, 2005.
- S. D. Westerheide, J. Anckar, S. M. Stevens Jr., L. Sistonen, and R. I. Morimoto, “Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT,” Science, vol. 323, no. 5917, pp. 1063–1066, 2009.
- H. Y. Cohen, C. Miller, K. J. Bitterman et al., “Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase,” Science, vol. 305, no. 5682, pp. 390–392, 2004.
- Z. Ungvari, R. Buffenstein, S. N. Austad, A. Podlutsky, G. Kaley, and A. Csiszar, “Oxidative stress in vascular senescence: lessons from successfully aging species,” Frontiers in Bioscience, vol. 13, no. 13, pp. 5056–5070, 2008.
- Heart Protection Study Collaborative Group, “MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20 536 high-risk individuals: a randomised placebo-controlled trial,” The Lancet, vol. 360, no. 9326, pp. 23–33, 2002.
- N. Ferrara, B. Rinaldi, G. Corbi et al., “Exercise training promotes SIRT1 activity in aged rats,” Rejuvenation Research, vol. 11, no. 1, pp. 139–150, 2008.
- P. Abete, N. Ferrara, F. Cacciatore et al., “High level of physical activity preserves the cardioprotective effect of preinfarction angina in elderly patients,” Journal of the American College of Cardiology, vol. 38, no. 5, pp. 1357–1365, 2001.
- D. Leosco, G. Rengo, G. Iaccarino et al., “Exercise promotes angiogenesis and improves β-adrenergic receptor signalling in the post-ischaemic failing rat heart,” Cardiovascular Research, vol. 78, no. 2, pp. 385–394, 2008.
- G. Rengo, D. Leosco, C. Zincarelli et al., “Adrenal GRK2 lowering is an underlying mechanism for the beneficial sympathetic effects of exercise training in heart failure,” American Journal of Physiology—Heart and Circulatory Physiology, vol. 298, no. 6, pp. H2032–H2038, 2010.
- P. Abete, C. Calabrese, N. Ferrara et al., “Exercise training restores ischemic preconditioning in the aging heart,” Journal of the American College of Cardiology, vol. 36, no. 2, pp. 643–650, 2000.
- P. Abete, G. Testa, G. Galizia et al., “Tandem action of exercise training and food restriction completely preserves ischemic preconditioning in the aging heart,” Experimental Gerontology, vol. 40, no. 1-2, pp. 43–50, 2005.
- P. Abete, G. Testa, N. Ferrara et al., “Cardioprotective effect of ischemic preconditioning is preserved in food-restricted senescent rats,” American Journal of Physiology, vol. 282, no. 6, pp. H1978–H1987, 2002.
- E. Nisoli, C. Tonello, L. Briscini, and M. O. Carruba, “Inducible nitric oxide synthase in rat brown adipocytes: implications for blood flow to brown adipose tissue,” Endocrinology, vol. 138, no. 2, pp. 676–682, 1997.
- R. Lee, M. Margaritis, K. M. Channon, and C. Antoniades, “Evaluating oxidative stress in human cardiovascular disease: methodological aspects and considerations,” Current Medicinal Chemistry, vol. 19, no. 16, pp. 2504–2520, 2012.
- H. T. Yang, B. M. Prior, P. G. Lloyd et al., “Training-induced vascular adaptations to ischemic muscle,” Journal of Physiology and Pharmacology, vol. 59, no. 7, pp. 57–70, 2008.
- S. Eksakulkla, D. Suksom, P. Siriviriyakul, and S. Patumraj, “Increased NO bioavailability in aging male rats by genistein and exercise training: using 4, 5-diaminofluorescein diacetate,” Reproductive Biology and Endocrinology, vol. 7, article 93, 2009.
- F. Cacciatore, P. Abete, S. Maggi et al., “Disability and 6-year mortality in elderly population. Role of visual impairment,” Aging—Clinical and Experimental Research, vol. 16, no. 5, pp. 382–388, 2004.
- V. Conti, G. Corbi, G. Russomanno et al., “Oxidative stress effects on endothelial cells treated with different athletes' sera,” Medicine & Science in Sports & Exercise, vol. 44, no. 1, pp. 39–49, 2012.
- J. S. Allard, L. K. Heilbronn, C. Smith et al., “In vitro cellular adaptations of indicators of longevity in response to treatment with serum collected from humans on calorie restricted diets,” PLoS ONE, vol. 3, no. 9, Article ID e3211, 2008.
- A. Hassid, J. Yao, and S. Huang, “NO alters cell shape and motility in aortic smooth muscle cells via protein tyrosine phosphatase 1B activation,” American Journal of Physiology, vol. 277, no. 3, pp. H1014–H1026, 1999.
- F. Fazio, L. Lionetto, G. Molinaro, et al., “Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors,” Molecular Pharmacology, vol. 81, no. 5, pp. 643–656, 2012.
- I. Sato, I. Morita, K. Kaji, M. Ikeda, M. Nagao, and S. Murota, “Reduction of nitric oxide producing activity associated with in vitro aging in cultured human umbilical vein endothelial cell,” Biochemical and Biophysical Research Communications, vol. 195, no. 2, pp. 1070–1076, 1993.
- D. F. Dai and P. S. Rabinovitch, “Cardiac aging in mice and humans: the role of mitochondrial oxidative stress,” Trends in Cardiovascular Medicine, vol. 19, no. 7, pp. 213–220, 2009.
- D. Dutta, R. Calvani, R. Bernabei, C. Leeuwenburgh, and E. Marzetti, “Contribution of impaired mitochondrial autophagy to cardiac aging: mechanisms and therapeutic opportunities,” Circulation Research, vol. 110, no. 8, pp. 1125–1138, 2012.
- Z. Ungvári, S. A. Gupte, F. A. Recchia, S. Bátkai, and P. Pacher, “Role of oxidative-nitrosative stress and downstream pathways in various forms of cardiomyopathy and heart failure,” Current Vascular Pharmacology, vol. 3, no. 3, pp. 221–229, 2005.
- J. Downing and G. J. Balady, “The role of exercise training in heart failure,” Journal of the American College of Cardiology, vol. 58, no. 6, pp. 561–569, 2011.