About this Journal Submit a Manuscript Table of Contents
Oxidative Medicine and Cellular Longevity
Volume 2012 (2012), Article ID 728547, 6 pages
http://dx.doi.org/10.1155/2012/728547
Review Article

Is Physical Activity Able to Modify Oxidative Damage in Cardiovascular Aging?

1Department of Medicine and Health Sciences, University of Molise, Via Giovanni Paolo II, Località Tappino, 86100 Campobasso, Italy
2Department of Medicine and Sugery, University of Salerno, Via Salvador Allende, 84081 Baronissi (SA), Italy
3Istituto Scientifico di Campoli/Telese, Fondazione Salvatore Maugeri, IRCCS, Via Bagni Vecchi 1, 82037 Telese Terme (BN), Italy

Received 22 June 2012; Accepted 13 August 2012

Academic Editor: William C. Burhans

Copyright © 2012 Graziamaria Corbi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. G. Corbi, V. Conti, G. Scapagnini, A. Filippelli, and N. Ferrara, “Role of sirtuins, calorie restriction and physical activity in aging,” Frontiers in Bioscience (Elite Edition), vol. 4, pp. 768–778, 2012.
  2. S. Vasto, G. Scapagnini, M. Bulati et al., “Biomarkes of aging,” Frontiers in Bioscience (Scholar Edition), vol. 2, pp. 392–402, 2010. View at Scopus
  3. M. Galderisi, V. S. Lomoriello, A. Santoro, et al., “Differences of myocardial systolic deformation and correlates of diastolic function in competitive rowers and young hypertensives: a speckle-tracking echocardiography study,” Journal of the American Society of Echocardiography, vol. 23, no. 11, pp. 1190–1198, 2010. View at Publisher · View at Google Scholar
  4. C. H. Davies, N. Ferrara, and S. E. Harding, “β-Adrenoceptor function changes with age of subject in myocytes from non-failing human ventricle,” Cardiovascular Research, vol. 31, no. 1, pp. 152–156, 1996. View at Publisher · View at Google Scholar · View at Scopus
  5. P. Abete, C. Napoli, G. Santoro et al., “Age-related decrease in cardiac tolerance to oxidative stress,” Journal of Molecular and Cellular Cardiology, vol. 31, no. 1, pp. 227–236, 1999. View at Publisher · View at Google Scholar · View at Scopus
  6. S. Besse, C. Delcayre, B. Chevalier et al., “Is the senescent heart overloaded and already failing?” Cardiovascular Drugs and Therapy, vol. 8, no. 4, pp. 581–587, 1994. View at Publisher · View at Google Scholar · View at Scopus
  7. G. Vitale, M. Galderisi, A. Colao, et al., “Circulating IGF-I levels are associated with increased biventricular contractility in top-level rowers,” Clinical Endocrinology (Oxford), vol. 69, no. 2, pp. 231–236, 2008. View at Publisher · View at Google Scholar
  8. N. Ferrara, P. Abete, G. Corbi et al., “Insulin-induced changes in β-adrenergic response: an experimental study in the isolated rat papillary muscle,” American Journal of Hypertension, vol. 18, no. 3, pp. 348–353, 2005. View at Publisher · View at Google Scholar · View at Scopus
  9. L. Amato, G. Paolisso, F. Cacciatore, et al., “Congestive heart failure predicts the development of non-insulin-dependent diabetes mellitus in the elderly. The Osservatorio Geriatrico Regione Campania Group,” Diabetes and Metabolism, vol. 23, no. 3, pp. 213–218, 1997.
  10. M. Zheng, W. Zhu, Q. Han, and R. P. Xiao, “Emerging concepts and therapeutic implications of β-adrenergic receptor subtype signaling,” Pharmacology and Therapeutics, vol. 108, no. 3, pp. 257–268, 2005. View at Publisher · View at Google Scholar · View at Scopus
  11. N. Ferrara, K. Davia, P. Abete, F. Rengo, and S. E. Harding, “Alterations in β-adrenoceptor mechanisms in the aging heart. Relationship with heart failure,” Aging—Clinical and Experimental Research, vol. 9, no. 6, pp. 391–403, 1997. View at Scopus
  12. G. Rengo, C. Zincarelli, G. D. Femminella et al., “Myocardial β2-adrenoceptor gene delivery promotes coordinated cardiac adaptive remodelling and angiogenesis in heart failure,” British Journal of Pharmacology, vol. 166, no. 8, pp. 2348–2361, 2012. View at Publisher · View at Google Scholar · View at Scopus
  13. G. Rengo, A. Lymperopoulos, C. Zincarelli et al., “Blockade of β-adrenoceptors restores the GRK2-mediated adrenal α2-adrenoceptor-catecholamine production axis in heart failure,” British Journal of Pharmacology, vol. 166, no. 8, pp. 2430–2440, 2012. View at Publisher · View at Google Scholar · View at Scopus
  14. G. Corbi, D. Acanfora, G. L. Iannuzzi et al., “Hypermagnesemia predicts mortality in elderly with congestive heart disease: relationship with laxative and antacid use,” Rejuvenation Research, vol. 11, no. 1, pp. 129–138, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. K. L. Koss and R. D. Grubbs, “Elevated extracellular Mg2+ increases Mg2+ buffering through a Ca-dependent mechanism in cardiomyocytes,” American Journal of Physiology, vol. 267, no. 2, pp. C633–C641, 1994. View at Scopus
  16. S. Kawano, “Dual mechanisms of Mg2+ block of ryanodine receptor Ca2+ release channel from cardiac sarcoplasmic reticulum,” Receptors and Channels, vol. 5, no. 6, pp. 405–416, 1998. View at Scopus
  17. G. Longobardi, P. Abete, N. Ferrara et al., “‘Warm-up’ phenomenon in adult and elderly patients with coronary artery disease: further evidence of the loss of “ischemic preconditioning” in the aging heart,” Journals of Gerontology—Series A, vol. 55, no. 3, pp. M124–M129, 2000. View at Scopus
  18. P. Abete, A. Cioppa, C. Calabrese et al., “Ischemic threshold and myocardial stunning in the aging heart,” Experimental Gerontology, vol. 34, no. 7, pp. 875–884, 1999. View at Publisher · View at Google Scholar · View at Scopus
  19. C. P. Campobasso, A. S. Dell'Erba, A. Addante, F. Zotti, A. Marzullo, and M. F. Colonna, “Sudden cardiac death and myocardial ischemia indicators: a comparative study of four immunohistochemical markers,” American Journal of Forensic Medicine and Pathology, vol. 29, no. 2, pp. 154–161, 2008. View at Publisher · View at Google Scholar · View at Scopus
  20. N. Ferrara, P. Abete, G. Ambrosio et al., “Protective role of chronic ubiquinone administration on acute cardiac oxidative stress,” Journal of Pharmacology and Experimental Therapeutics, vol. 274, no. 2, pp. 858–865, 1995. View at Scopus
  21. B. Rinaldi, G. Corbi, S. Boccuti et al., “Exercise training affects age-induced changes in SOD and heat shock protein expression in rat heart,” Experimental Gerontology, vol. 41, no. 8, pp. 764–770, 2006. View at Publisher · View at Google Scholar · View at Scopus
  22. A. Navarro-Arévalo, C. Cañavate, and M. J. Sánchez-del-Pino, “Myocardial and skeletal muscle aging and changes in oxidative stress in relationship to rigorous exercise training,” Mechanisms of Ageing and Development, vol. 108, no. 3, pp. 207–217, 1999. View at Publisher · View at Google Scholar · View at Scopus
  23. P. K. Singal, A. Petkau, J. M. Gerrard, S. Hrushovetz, and J. Foerster, “Free radicals in health and disease,” Molecular and Cellular Biochemistry, vol. 84, no. 2, pp. 121–122, 1988. View at Scopus
  24. F. Gündüz, U. K. Sentürk, O. Kuru, B. Aktekin, and M. R. Aktekin, “The effect of one year's swimming exercise on oxidant stress and antioxidant capacity in aged rats,” Physiological Research, vol. 53, no. 2, pp. 171–176, 2004. View at Scopus
  25. J. L. Martin, R. Mestril, R. Hilal-Dandan, L. L. Brunton, and W. H. Dillmann, “Small heat shock proteins and protection against ischemic injury in cardiac myocytes,” Circulation, vol. 96, no. 12, pp. 4343–4348, 1997. View at Scopus
  26. L. H. E. H. Snoeckx, R. N. Cornelussen, F. A. Van Nieuwenhoven, R. S. Reneman, and G. J. Van Der Vusse, “Heat shock proteins and cardiovascular pathophysiology,” Physiological Reviews, vol. 81, no. 4, pp. 1461–1497, 2001. View at Scopus
  27. P. Anversa, B. Hiler, R. Ricci, G. Guideri, and G. Olivetti, “Myocyte cell loss and myocyte hypertrophy in the aging rat heart,” Journal of the American College of Cardiology, vol. 8, no. 6, pp. 1441–1448, 1986. View at Scopus
  28. S. Besse, V. Robert, P. Assayag, C. Delcayre, and B. Swynghedauw, “Nonsynchronous changes in myocardial collagen mRNA and protein during aging: effect of DOCA-salt hypertension,” American Journal of Physiology, vol. 267, no. 6, pp. H2237–H2244, 1994. View at Scopus
  29. M. Klima, T. R. Burns, and A. Chopra, “Mycardial fibrosis in the elderly,” Archives of Pathology and Laboratory Medicine, vol. 114, no. 9, pp. 938–942, 1990. View at Scopus
  30. O. Grubisha, B. C. Smith, and J. M. Denu, “Small molecule regulation of Sir2 protein deacetylases,” FEBS Journal, vol. 272, no. 18, pp. 4607–4616, 2005. View at Publisher · View at Google Scholar · View at Scopus
  31. A. Brunet, L. B. Sweeney, J. F. Sturgill et al., “Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase,” Science, vol. 303, no. 5666, pp. 2011–2015, 2004. View at Publisher · View at Google Scholar · View at Scopus
  32. M. Porcu and A. Chiarugi, “The emerging therapeutic potential of sirtuin-interacting drugs: from cell death to lifespan extension,” Trends in Pharmacological Sciences, vol. 26, no. 2, pp. 94–103, 2005. View at Publisher · View at Google Scholar · View at Scopus
  33. S. D. Westerheide, J. Anckar, S. M. Stevens Jr., L. Sistonen, and R. I. Morimoto, “Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT,” Science, vol. 323, no. 5917, pp. 1063–1066, 2009. View at Publisher · View at Google Scholar · View at Scopus
  34. H. Y. Cohen, C. Miller, K. J. Bitterman et al., “Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase,” Science, vol. 305, no. 5682, pp. 390–392, 2004. View at Publisher · View at Google Scholar · View at Scopus
  35. Z. Ungvari, R. Buffenstein, S. N. Austad, A. Podlutsky, G. Kaley, and A. Csiszar, “Oxidative stress in vascular senescence: lessons from successfully aging species,” Frontiers in Bioscience, vol. 13, no. 13, pp. 5056–5070, 2008. View at Publisher · View at Google Scholar · View at Scopus
  36. Heart Protection Study Collaborative Group, “MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20 536 high-risk individuals: a randomised placebo-controlled trial,” The Lancet, vol. 360, no. 9326, pp. 23–33, 2002. View at Publisher · View at Google Scholar · View at Scopus
  37. N. Ferrara, B. Rinaldi, G. Corbi et al., “Exercise training promotes SIRT1 activity in aged rats,” Rejuvenation Research, vol. 11, no. 1, pp. 139–150, 2008. View at Publisher · View at Google Scholar · View at Scopus
  38. P. Abete, N. Ferrara, F. Cacciatore et al., “High level of physical activity preserves the cardioprotective effect of preinfarction angina in elderly patients,” Journal of the American College of Cardiology, vol. 38, no. 5, pp. 1357–1365, 2001. View at Publisher · View at Google Scholar · View at Scopus
  39. D. Leosco, G. Rengo, G. Iaccarino et al., “Exercise promotes angiogenesis and improves β-adrenergic receptor signalling in the post-ischaemic failing rat heart,” Cardiovascular Research, vol. 78, no. 2, pp. 385–394, 2008. View at Publisher · View at Google Scholar · View at Scopus
  40. G. Rengo, D. Leosco, C. Zincarelli et al., “Adrenal GRK2 lowering is an underlying mechanism for the beneficial sympathetic effects of exercise training in heart failure,” American Journal of Physiology—Heart and Circulatory Physiology, vol. 298, no. 6, pp. H2032–H2038, 2010. View at Publisher · View at Google Scholar · View at Scopus
  41. P. Abete, C. Calabrese, N. Ferrara et al., “Exercise training restores ischemic preconditioning in the aging heart,” Journal of the American College of Cardiology, vol. 36, no. 2, pp. 643–650, 2000. View at Publisher · View at Google Scholar · View at Scopus
  42. P. Abete, G. Testa, G. Galizia et al., “Tandem action of exercise training and food restriction completely preserves ischemic preconditioning in the aging heart,” Experimental Gerontology, vol. 40, no. 1-2, pp. 43–50, 2005. View at Publisher · View at Google Scholar · View at Scopus
  43. P. Abete, G. Testa, N. Ferrara et al., “Cardioprotective effect of ischemic preconditioning is preserved in food-restricted senescent rats,” American Journal of Physiology, vol. 282, no. 6, pp. H1978–H1987, 2002. View at Scopus
  44. E. Nisoli, C. Tonello, L. Briscini, and M. O. Carruba, “Inducible nitric oxide synthase in rat brown adipocytes: implications for blood flow to brown adipose tissue,” Endocrinology, vol. 138, no. 2, pp. 676–682, 1997. View at Publisher · View at Google Scholar · View at Scopus
  45. R. Lee, M. Margaritis, K. M. Channon, and C. Antoniades, “Evaluating oxidative stress in human cardiovascular disease: methodological aspects and considerations,” Current Medicinal Chemistry, vol. 19, no. 16, pp. 2504–2520, 2012.
  46. H. T. Yang, B. M. Prior, P. G. Lloyd et al., “Training-induced vascular adaptations to ischemic muscle,” Journal of Physiology and Pharmacology, vol. 59, no. 7, pp. 57–70, 2008. View at Scopus
  47. S. Eksakulkla, D. Suksom, P. Siriviriyakul, and S. Patumraj, “Increased NO bioavailability in aging male rats by genistein and exercise training: using 4, 5-diaminofluorescein diacetate,” Reproductive Biology and Endocrinology, vol. 7, article 93, 2009. View at Publisher · View at Google Scholar · View at Scopus
  48. F. Cacciatore, P. Abete, S. Maggi et al., “Disability and 6-year mortality in elderly population. Role of visual impairment,” Aging—Clinical and Experimental Research, vol. 16, no. 5, pp. 382–388, 2004.
  49. V. Conti, G. Corbi, G. Russomanno et al., “Oxidative stress effects on endothelial cells treated with different athletes' sera,” Medicine & Science in Sports & Exercise, vol. 44, no. 1, pp. 39–49, 2012. View at Publisher · View at Google Scholar · View at Scopus
  50. J. S. Allard, L. K. Heilbronn, C. Smith et al., “In vitro cellular adaptations of indicators of longevity in response to treatment with serum collected from humans on calorie restricted diets,” PLoS ONE, vol. 3, no. 9, Article ID e3211, 2008. View at Publisher · View at Google Scholar · View at Scopus
  51. A. Hassid, J. Yao, and S. Huang, “NO alters cell shape and motility in aortic smooth muscle cells via protein tyrosine phosphatase 1B activation,” American Journal of Physiology, vol. 277, no. 3, pp. H1014–H1026, 1999. View at Scopus
  52. F. Fazio, L. Lionetto, G. Molinaro, et al., “Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors,” Molecular Pharmacology, vol. 81, no. 5, pp. 643–656, 2012. View at Publisher · View at Google Scholar
  53. I. Sato, I. Morita, K. Kaji, M. Ikeda, M. Nagao, and S. Murota, “Reduction of nitric oxide producing activity associated with in vitro aging in cultured human umbilical vein endothelial cell,” Biochemical and Biophysical Research Communications, vol. 195, no. 2, pp. 1070–1076, 1993. View at Publisher · View at Google Scholar · View at Scopus
  54. D. F. Dai and P. S. Rabinovitch, “Cardiac aging in mice and humans: the role of mitochondrial oxidative stress,” Trends in Cardiovascular Medicine, vol. 19, no. 7, pp. 213–220, 2009. View at Publisher · View at Google Scholar · View at Scopus
  55. D. Dutta, R. Calvani, R. Bernabei, C. Leeuwenburgh, and E. Marzetti, “Contribution of impaired mitochondrial autophagy to cardiac aging: mechanisms and therapeutic opportunities,” Circulation Research, vol. 110, no. 8, pp. 1125–1138, 2012. View at Publisher · View at Google Scholar
  56. Z. Ungvári, S. A. Gupte, F. A. Recchia, S. Bátkai, and P. Pacher, “Role of oxidative-nitrosative stress and downstream pathways in various forms of cardiomyopathy and heart failure,” Current Vascular Pharmacology, vol. 3, no. 3, pp. 221–229, 2005. View at Publisher · View at Google Scholar · View at Scopus
  57. J. Downing and G. J. Balady, “The role of exercise training in heart failure,” Journal of the American College of Cardiology, vol. 58, no. 6, pp. 561–569, 2011. View at Publisher · View at Google Scholar · View at Scopus