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Oxidative Medicine and Cellular Longevity
Volume 2012 (2012), Article ID 750963, 10 pages
http://dx.doi.org/10.1155/2012/750963
Research Article

Antiaging Effect of Pine Pollen in Human Diploid Fibroblasts and in a Mouse Model Induced by D-Galactose

1Zhejiang Provincial Key Lab of Geriatrics, Zhejiang Hospital, 12 Lingyin Road, Hangzhou 310013, China
2Zhejiang Forestry Academy, Hangzhou 310023, China

Received 2 December 2011; Revised 10 February 2012; Accepted 14 February 2012

Academic Editor: Guilherme Antonio Behr

Copyright © 2012 Gen-Xiang Mao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. H. Wei, L. Li, Q. Song, H. Ai, J. Chu, and W. Li, “Behavioural study of the D-galactose induced aging model in C57BL/6J mice,” Behavioural Brain Research, vol. 157, no. 2, pp. 245–251, 2005. View at Publisher · View at Google Scholar · View at Scopus
  2. S. C. Ho, J. H. Liu, and R. Y. Wu, “Establishment of the mimetic aging effect in mice caused by D-galactose,” Biogerontology, vol. 4, no. 1, pp. 15–18, 2003. View at Publisher · View at Google Scholar · View at Scopus
  3. D. Y. Yoo, W. Kim, C. H. Lee et al., “Melatonin improves D-galactose-induced aging effects on behavior, neurogenesis, and lipid peroxidation in the mouse dentate gyrus via increasing pCREB expression,” Journal of Pineal Research, vol. 52, no. 1, pp. 21–28, 2012. View at Publisher · View at Google Scholar
  4. A. Kumar, A. Prakash, and S. Dogra, “Centella asiatica attenuates d-galactose-induced cognitive impairment, oxidative and mitochondrial dysfunction in mice,” International Journal of Alzheimer's Disease, vol. 2011, Article ID 347569, 9 pages, 2011. View at Publisher · View at Google Scholar
  5. X. Song, M. Bao, D. Li, and Y. M. Li, “Advanced glycation in D-galactose induced mouse aging model,” Mechanisms of Ageing and Development, vol. 108, no. 3, pp. 239–251, 1999. View at Publisher · View at Google Scholar · View at Scopus
  6. H. Vlassara, R. Bucala, and L. Striker, “Pathogenic effects of advanced glycosylation: biochemical, biologic, and clinical implications for diabetes and aging,” Laboratory Investigation, vol. 70, no. 2, pp. 138–151, 1994. View at Scopus
  7. M. A. Smith, L. M. Sayre, V. M. Monnier, and G. Perry, “Radical AGEing in Alzheimer's disease,” Trends in Neurosciences, vol. 18, no. 4, pp. 172–176, 1995. View at Publisher · View at Google Scholar · View at Scopus
  8. J. Tian, K. Ishibashi, K. Ishibashi et al., “Advanced glycation endproduct-induced aging of the retinal pigment epithelium and choroid: a comprehensive transcriptional response,” Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 33, pp. 11846–11851, 2005. View at Publisher · View at Google Scholar · View at Scopus
  9. R. D. Semba, E. J. Nicklett, and L. Ferrucci, “Does accumulation of advanced glycation end products contribute to the aging phenotype?” Journals of Gerontology A, vol. 65, no. 9, pp. 963–975, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. E. R. Stadtman, “Protein oxidation and aging,” Science, vol. 257, no. 5074, pp. 1220–1224, 1992. View at Scopus
  11. S. Y. Li, V. K. Sigmon, S. A. Babcock, and J. Ren, “Advanced glycation endproduct induces ROS accumulation, apoptosis, MAP kinase activation and nuclear O-GlcNAcylation in human cardiac myocytes,” Life Sciences, vol. 80, no. 11, pp. 1051–1056, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. X. He, X. Sun, and Z. Yu, “Effective components and pharmacological function of pine pollen,” Journal of Northeast Forestry University, vol. 35, no. 9, pp. 78–80, 2007.
  13. K. H. Lee and E. M. Choi, “Effect of pine pollen extract on experimental chronic arthritis,” Phytotherapy Research, vol. 23, no. 5, pp. 651–657, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. K. H. Lee, A. J. Kim, and E. M. Choi, “Antioxidant and antiinflammatory activity of pine pollen extract in vitro,” Phytotherapy Research, vol. 23, no. 1, pp. 41–48, 2009. View at Publisher · View at Google Scholar · View at Scopus
  15. J. Li, Z. Zhang, and T. Tong, “The proliferative response and anti-oncogene expression in old 2BS cells after growth factor stimulation,” Mechanisms of Ageing and Development, vol. 80, no. 1, pp. 25–34, 1995. View at Publisher · View at Google Scholar · View at Scopus
  16. P. Wang, Z. Zhang, X. Ma et al., “HDTIC-1 and HDTIC-2, two compounds extracted from Astragali Radix, delay replicative senescence of human diploid fibroblasts,” Mechanisms of Ageing and Development, vol. 124, no. 10–12, pp. 1025–1034, 2003. View at Publisher · View at Google Scholar · View at Scopus
  17. G. X. Mao, Y. Wang, Q. Qiu et al., “Salidroside protects human fibroblast cells from premature senescence induced by H2O2 partly through modulating oxidative status,” Mechanisms of Ageing and Development, vol. 131, no. 11-12, pp. 723–731, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. G. X. Mao, H. B. Deng, L. G. Yuan, D. D. Li, Y. Y. Y. Li, and Z. Wang, “Protective role of salidroside against aging in a mouse model induced by D-galactose,” Biomedical and Environmental Sciences, vol. 23, no. 2, pp. 161–166, 2010. View at Publisher · View at Google Scholar · View at Scopus
  19. Z. Tang, Z. Zhang, Y. Zheng, M. J. Corbley, and T. Tong, “Cell aging of human diploid fibroblasts is associated with changes in responsiveness to epidermal growth factor and changes in HER-2 expression,” Mechanisms of Ageing and Development, vol. 73, no. 1, pp. 57–67, 1994. View at Publisher · View at Google Scholar · View at Scopus
  20. D. P. Mangiameli, J. A. Blansfield, S. Kachala et al., “Combination therapy targeting the tumor microenvironment is effective in a model of human ocular melanoma,” Journal of Translational Medicine, vol. 5, article 38, 2007. View at Publisher · View at Google Scholar · View at Scopus
  21. G. P. Dimri, X. Lee, G. Basile et al., “A biomarker that identifies senescent human cells in culture and in aging skin in vivo,” Proceedings of the National Academy of Sciences of the United States of America, vol. 92, no. 20, pp. 9363–9367, 1995. View at Publisher · View at Google Scholar · View at Scopus
  22. S. Ahmadi, N. Malekmohammadi, and M. R. Zarrindast, “Repeated histamine pretreatment decreased amnesia induced by post-training administration of the drug in a step-down inhibitory avoidance test in mice,” Archives of Iranian Medicine, vol. 13, no. 3, pp. 209–216, 2010. View at Scopus
  23. Z. Makita, H. Vlassara, A. Cerami, and R. Bucala, “Immunochemical detection of advanced glycosylation end products in vivo,” Journal of Biological Chemistry, vol. 267, no. 8, pp. 5133–5138, 1992. View at Scopus
  24. F. Bringold and M. Serrano, “Tumor suppressors and oncogenes in cellular senescence,” Experimental Gerontology, vol. 35, no. 3, pp. 317–329, 2000. View at Publisher · View at Google Scholar · View at Scopus
  25. K. Alexander and P. W. Hinds, “Requirement for p27KIP1 in retinoblastoma protein-mediated senescence,” Molecular and Cellular Biology, vol. 21, no. 11, pp. 3616–3631, 2001. View at Publisher · View at Google Scholar · View at Scopus
  26. M. De Martinis, C. Franceschi, D. Monti, and L. Ginaldi, “Inflamm-ageing and lifelong antigenic load as major determinants of ageing rate and longevity,” FEBS Letters, vol. 579, no. 10, pp. 2035–2039, 2005. View at Publisher · View at Google Scholar · View at Scopus
  27. M. Lei, X. Hua, M. Xiao, J. Ding, Q. Han, and G. Hu, “Impairments of astrocytes are involved in the d-galactose-induced brain aging,” Biochemical and Biophysical Research Communications, vol. 369, no. 4, pp. 1082–1087, 2008. View at Publisher · View at Google Scholar · View at Scopus
  28. L. Hayflick, “The limited in vitro lifetime of human diploid cell strains,” Experimental Cell Research, vol. 37, no. 3, pp. 614–636, 1965. View at Scopus
  29. X. Cui, P. Zuo, Q. Zhang et al., “Chronic systemic D-galactose exposure induces memory loss, neurodegeneration, and oxidative damage in mice: protective effects of R-α-lipoic acid,” Journal of Neuroscience Research, vol. 84, no. 3, pp. 647–654, 2006. View at Publisher · View at Google Scholar · View at Scopus
  30. G. Guoqing and X. fuben, “Study of aging model in mice,” Journal of China Pharmaceutical University, vol. 22, no. 2, pp. 101–103, 1991. View at Scopus
  31. S. Pashikanti, D. R. de Alba, G. A. Boissonneault, and D. Cervantes-Laurean, “Rutin metabolites: novel inhibitors of nonoxidative advanced glycation end products,” Free Radical Biology and Medicine, vol. 48, no. 5, pp. 656–663, 2010. View at Publisher · View at Google Scholar · View at Scopus
  32. P. Urios, A. M. Grigorova-Borsos, and M. Sternberg, “Flavonoids inhibit the formation of the cross-linking AGE pentosidine in collagen incubated with glucose, according to their structure,” European Journal of Nutrition, vol. 46, no. 3, pp. 139–146, 2007. View at Publisher · View at Google Scholar · View at Scopus
  33. V. P. Reddy and A. Beyaz, “Inhibitors of the Maillard reaction and AGE breakers as therapeutics for multiple diseases,” Drug Discovery Today, vol. 11, no. 13-14, pp. 646–654, 2006. View at Publisher · View at Google Scholar · View at Scopus
  34. G. Basta, “Receptor for advanced glycation endproducts and atherosclerosis: from basic mechanisms to clinical implications,” Atherosclerosis, vol. 196, no. 1, pp. 9–21, 2008. View at Publisher · View at Google Scholar · View at Scopus