Inhibition of Mitochondrial Cytochrome c Release and Suppression of Caspases by Gamma-Tocotrienol Prevent Apoptosis and Delay Aging in Stress-Induced Premature Senescence of Skin Fibroblasts

Figure 10

Representative Western blot of proapoptotic protein (Bax) and antiapoptotic protein (Bcl-2) in HDFs (a). Comparison of Bax/Bcl-2 protein ratio and in different treatment groups (b). Data are expressed as means ± SD, 𝑛=6. ^adenotes 𝑃<0.05 compared to control young, ^b𝑃<0.05 compared to GTT, ^c𝑃<0.05 compared to SIPS and ^d𝑃<0.05 compared to control senescent cells.

(a)

(b)