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Oxidative Medicine and Cellular Longevity
Volume 2012 (2012), Article ID 789870, 5 pages
http://dx.doi.org/10.1155/2012/789870
Clinical Study

Oxidative Stress Markers in Prostate Cancer Patients after HDR Brachytherapy Combined with External Beam Radiation

1Department of Medical Biology, Faculty of Medicine, Nicolaus Copernicus University, Karłowicza 24 Street, 85-092 Bydgoszcz, Poland
2Department of Normal Anatomy, Faculty of Medicine, Nicolaus Copernicus University, Karłowicza 24 Street, 85-092 Bydgoszcz, Poland
3Department of Neurosurgery, Stanisław Staszic Specjalist Hospital, Rydygiera 1 Street, 64-920 Piła, Poland
4Department of Oncology and Brachytherapy, Faculty of Medicine, Nicolaus Copernicus University, Karłowicza 24 Street, 85-092 Bydgoszcz, Poland
5Franciszek Łukaszczyk Oncology Center, Romanowskiej 2 Street, 85-796 Bydgoszcz, Poland

Received 4 September 2012; Accepted 29 November 2012

Academic Editor: Ryuichi Morishita

Copyright © 2012 Alina Woźniak et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Assessment of oxidative stress markers was perfomed in prostate cancer (PCa) patients subjected to high-dose brachytherapy (HDR) with external beam radiotherapy (EBRT). Sixty men with PCa were subjected to combined two-fraction treatment with HDR (tot. 20 Gy) and EBRT (46 Gy). Blood samples were taken before treatment, immediately afterwards, after 1.5–3 months, and approx. 2 years. Control group consisted of 30 healthy men. Erythrocyte glutathione peroxidase activity in the patients was lower than in healthy subjects by 34% ( , 50% ( , 30% ( , and 61% ( , respectively, at all periods. No significant differences were found by comparing superoxide dismutase and catalase activity in PCa patients with that of the controls. After 2 years of the end of treatment, the activity of studied enzymes demonstrated a decreasing tendency versus before therapy. Blood plasma thiobarbituric acid reactive substances (TBARS) concentration was higher than in the controls at all periods, while erythrocyte TBARS decreased after 2 years to control levels. The results confirm that in the course of PCa, imbalance of oxidant-antioxidant processes occurs. The therapy did not alter the levels of oxidative stress markers, which may prove its applicability. Two years is too short a period to restore the oxidant-antioxidant balance.