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Figure 4: Molecular mechanisms by which the coadministration of LA plus Q10 may improve skeletal muscle energy metabolism and integrity. LA plus Q10 induce the transcription factor PGC1α which may activate TFAM. Furthermore, LA plus Q10 induce GSTs and genes encoding enzymes involved in GSH synthesis and recycling. Ultimately, LA plus Q10 may increase mitochondrial biogenesis, improve stress response, and increase cellular GSH levels.