Accumulation of Exogenous Amyloid-Beta Peptide in Hippocampal Mitochondria Causes Their Dysfunction: A Protective Role for Melatonin

Figure 2

A cholesterol-enriched diet was significantly related to a more important loss of the mitochondrial integrity in animals. The graph shows differences among PBS-injected brains from animals receiving a regular laboratory rodent diet and two other groups of amyloid-injected brains. These latter were from animals receiving a normal diet and from animals receiving a cholesterol-enriched diet. Amyloid-injected brains showed significant loss of mitochondrial membrane integrity as compared to PBS-injected brains. However, those animals additionally fed with a cholesterol-enriched diet were significantly more affected.