Accumulation of Exogenous Amyloid-Beta Peptide in Hippocampal Mitochondria Causes Their Dysfunction: A Protective Role for Melatonin
Figure 5
Melatonin reduces significantly mitochondrial ROS overproduction. As expected, melatonin reduced the fluorescence derived from CM-H2XRos oxidation in both the fAβ- and the H2O2-injected brains. According to Figure 4 most of the mitochondria in brains injected with Aβ or H2O2 were producing free radicals. Now, by comparing the intensity of free radicals produced in brain of animals receiving melatonin treatment against those animals without melatonin, a very significant decrease in the amount of produced free radicals was observed, as shown in the graph.
