Table 1: Functional categories of proteins identified as increasingly modified in aging and age-related diseases. Fisher exact test was used and the value refers to the probability that each biological function assigned is due to chance alone.

Function valueModified proteins

Inflammatory response ACO2, ACTB, ALDH2, ALDOA, ARG1, ENO1, GAPDH, HSPA5, P4HB, PDIA3, PRDX1, PRDX6, SELENBP1, TKT, TPI1
Carbohydrate metabolism ALDOA, ENO1, ENO2, FBP1, GAPDH, PGAM1, PGK1, PKLR, PKM2, TPI1, ACADM
Nucleic acid metabolism ACOT8, ALDH2, ATP5A1, ATP5B, CKM, DPYSL2, GNB1, SCP2, SUCLA2, MDH2
Cell death ACAT1, ANXA2, ARG1, ATP5A1, G6PD, G5TM5, HSPD1, SLC1A2, PIN1, PRDX2, PARK7, TUBA1A
Lipid metabolism MDH1, MDH2, SDHA, SDHB, OGDH, SUCLA2, ACOT8, FABP4, GSTP1, SCP2
Free radical scavenging ALB, SOD1, SOD2, PRDX1, PRDX2, PRDX6, VDAC1, ALDH2, GPX1
Protein folding HSP90AA1, HSPA1A, ERP29, HSPD1, HSPA8, HSP90AB1
Amino acid metabolism ARG1, DDAH1, IVD, OAT, PAH, CKM, PLOD3
Protein synthesis EEF2, GNB2L1, RPS6KB1, TUFM, WARS, CCDC92
Cell migration AP2M1, FSCN1, GNB1, TPM1, VIM, ACTB, TAGLN2