Association of Base Excision Repair Gene Polymorphisms with ESRD Risk in a Chinese Population

Table 4

Genotypes of genetic polymorphisms in OGG1 and MUTYH and their effects on HD risk of patients with primary diagnoses of glomerulonephritis, hypertension, and anemia.

Genotype	Controls (𝑛=404)	Primary glomerulonephritis (𝑛=207)			Anemia (𝑛=267)			Hypertension (𝑛=250)
			P value^a	OR (95% CI)		P value^b	OR (95% CI)		P value^c	OR (95% CI)
OGG1 c.977 C > G
CC or CG	277 (68.6%)	132 (63.8%)		1.00	178 (66.7%)		1.00	158 (63.2%)		1.00
GG	127 (31.4%)	75 (36.2%)	0.233	1.24 (0.87–1.76)	89 (33.3%)	0.607	1.09 (0.78–1.52)	92 (36.8%)	0.158	1.27 (0.91–1.78)
MUTYH c.972 G > C
CC or CG	274 (67.8%)	113 (54.6%)		1.00	253 (57.3%)		1.00	147 (58.8%)		1.00
GG	130 (32.2%)	94 (45.4%)	0.001	1.75 (1.24–2.47)	114 (42.7%)	0.006	1.57 (1.14–2.16)	103 (41.2%)	0.019	1.48 (1.07–2.05)
AluYb8MUTYH
A/A	151 (37.4%)	53 (25.6%)		1.00	71 (26.6%)		1.00	74 (29.6%)		1.00
A/P or P/P	253 (62.6%)	154 (74.4%)	0.003	1.73 (1.20–2.52)	196 (73.4%)	0.004	1.65 (1.18–2.31)	176 (70.4%)	0.042	1.42 (1.01–1.99)

Note: CI: confidence interval; OR: odds ratio. P value for comparison using 𝜒²-test and trend test assessing correlation with HD risk among subgroup of primary glomerulonephritis a, anemia b, and hypertension c, compared with the healthy controls.