Anticancer Activity of Green Tea Polyphenols in Prostate Gland

Table 4

Studies on the effect of GTCs administration to TRAMP mice and humans with PCa.

Experimental groups	GTCs dose g/100 mL [oral administration]	Formulation (%)	PCa phases age-dependent (weeks)	PCa inhibition (%)	References
TRAMP mice	0.06	GTCs^a	Start 5; end 12	83	[61]
		EGCG (93)
	0.1	GTCs^b:	Start 8; end 32	42	[53]
		EGCG (62)
		ECG (24)
		EGC (5)
		EC (6)
	0.1	GTCs^b:			[62]
		EGCG (62)	Start 6; end 38	~50
		ECG (24)
		EGC (5)	Start 18; end 24	~20
		EC (6)
	0.3	GTCs^c:	Start 8; end 24	80	[19]
		EGC (5.5),
		EC (12.2)
		EGCG (51.9)
		ECG (6.1)
	GTCs dose mg/day [oral administration]	GTCs providers	PCa phases	Percentage (%) of PCa inhibition	References
HUMANS	500	Sabinsa Corporation	CRPC	No effect	[63]
	6000	Unilever	CRPC	No effect	[64]
	1300	Polyphenon E Matsui Norin,	CRPC	Mild effect	[86]
	600	Polyphenon E Matsui Norin	HGPIN	33	[65]
	800	Polyphenon E Matsui Norin	CRPC	No effect	[85]

GTCs^a: Roche, GTCs^b: natural resources and products, GTCs^c: isolated by the investigators; CRPC (castration resistant prostate cancer), HGPIN (high grade prostatic intraepithelial neoplasia).