Group VIB Phospholipase A2 Promotes Proliferation of INS-1 Insulinoma Cells and Attenuates Lipid Peroxidation and Apoptosis Induced by Inflammatory Cytokines and Oxidant Agents
Figure 2
Influence of the oxidant agents streptozotocin (STZ) and tert-butylhydroperoxide (TBHP) on iPLA 2γ expression by INS-1 cells. Control INS-1 cells were incubated with various concentrations of STZ (panel (a)) or TBHP (panel (b)) for 16 hr, and iPLA2γ mRNA levels were then determined by quantitative PCR, as in Figure 1(a). Mean values ± SEM () are displayed, and an asterisk (*) indicates a significant difference () from the condition in which the concentration of the oxidant agent was zero.
