Neuroprotective Effects of Hesperidin, a Plant Flavanone, on Rotenone-Induced Oxidative Stress and Apoptosis in a Cellular Model for Parkinson’s Disease
Figure 1
Effect of hesperidin on rotenone-induced reduction in cell proliferation in SK-N-SH neuroblastoma cells. (a) The dose-dependent effect of rotenone (0.5, 5, 50, 100, and 200 nM) on cell proliferation after 24 h. Values are presented as mean ± SD of four experiments in each group. 50% inhibition concentration value (IC50) was found to be 100 nM. * indicates significance compared to nontreated cells. (b) The dose-dependent effect of hesperidin (2.5, 5, 10, 20, and 40 μg) alone and against rotenone-induced changes on cell proliferation. Values are presented as mean ± SD of four experiments in each group. Treatment with hesperidin alone (blue column) (2.5, 5, 10, 20, and 40 μg) did not affect cell proliferation. Hesperidin (2.5, 5, 10, and 20 μg) pretreatment dose dependently enhanced cell proliferation against rotenone toxicity.
