Neuroprotective Effects of Hesperidin, a Plant Flavanone, on Rotenone-Induced Oxidative Stress and Apoptosis in a Cellular Model for Parkinson’s Disease

<table>Measurement of intracellular ATP levels. Rotenone (100 nM) treatment significantly reduced the levels of ATP as compared to control cells, while hesperidin (20 <i>μ</i>g) pretreatment significantly enhanced the levels of ATP as compared to rotenone alone treated cells. Values are given as mean <svg height="9.5625" id="M15" style="vertical-align:-0.3003pt" version="1.1" viewbox="0 0 10.1 9.5625" width="10.1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> compared to control, and <svg height="15.775" id="M17" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 67.387497 15.775" width="67.387497" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> compared to rotenone group (DMRT).</table>

Oxidative Medicine and Cellular Longevity

fig4

Figure 4

Figure 4: Neuroprotective Effects of Hesperidin, a Plant Flavanone, on Rotenone-Induced Oxidative Stress and Apoptosis in a Cellular Model for Parkinson’s Disease 

Figure 4 | Neuroprotective Effects of Hesperidin, a Plant Flavanone, on Rotenone-Induced Oxidative Stress and Apoptosis in a Cellular Model for Parkinson’s Disease 